T6575

TOFA

≥98% (HPLC)

• Synonym(e): 5-(Tetradecyloxy)-2-furoic acid
• Empirische Formel (Hill-System): C₁₉H₃₂O₄
• CAS-Nummer: 54857-86-2
• Molekulargewicht: 324.45
• NACRES: NA.77
• PubChem Substance ID: 329826849
• UNSPSC Code: 12352200
• MDL number: MFCD01726059
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• mp: 112-115 °C
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCCCOc1ccc(o1)C(O)=O
• InChI: 1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)
• InChI key: CZRCFAOMWRAFIC-UHFFFAOYSA-N

Beschreibung

Application

TOFA has been used as an ACC inhibitor to study its effect on insulin secretion in INS-1E cells.

TOFA has been used as a lipid biosynthesis inhibitor in mesenchymal stromal cells (MSCs), human pluripotent stem cells., an acetyl-CoA carboxylase 1 inhibitor in murine adipocyte cell lines., a lipolysis inhibitor in cancer stem cells (CSCs).

Biochem/physiol Actions

TOFA is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC).

TOFA is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC). TOFA is a key enzyme involved in fatty acid biosynthesis. TOFA inhibits cellular fatty acid synthesis in a dose-dependent manner (IC₅₀ = 4 μM in human breast cancer cell line MCF7).

Studies have reported that TOFA can inhibit the anorectic effect of subcutaneous tamoxifen (TMX) on food intake during refeeding experiments in rats.

5-(Tetradecyloxy)-2-furoic acid (TOFA) elicits hypolipidemic functionality by favoring fatty acid breakdown and at the same time preventing biosynthesis. It induces apoptosis in pancreatic cancer cells and favors tumor suppression.

Preparation Note

TOFA is soluble in DMSO at a concentration that is greater than 2 mg/ml.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)