T8938

Active Native Bovine Thyroid Stimulating Hormone

Lyophilized powder, ≥ 25IU/mg protein

• Synonym(e): TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands
• UNSPSC Code: 51111800
• Biological source: bovine pituitary glands
• Form: lyophilized powder

Eigenschaften

• biological source: bovine pituitary glands
• Quality Segment: 100
• form: lyophilized powder
• mol wt: (α subunit ≈ 13–15 kDa ; β subunit ≈ 15–17 kDa ; Total ≈ 28–32 kDa)
• purified by: chromatography
• suitability: suitable for molecular biology
• UniProt accession no.: P01223, P16473
• shipped in: wet ice
• storage temp.: -10 to -25°C
• target post-translational modification: disulfide bond
• Gene Information: bovine ... CGA(280749), TSHB(281552)

Beschreibung

General description

TSH is a heterodimeric glycoprotein hormone secreted by the anterior pituitary gland. It consists of a common α-subunit shared with other glycoprotein hormones (FSH, LH, and hCG) and a hormone-specific β-subunit that confers receptor specificity. Native bovine TSH is structurally conserved across mammalian species and exhibits biological activity through interaction with the thyroid-stimulating hormone receptor (TSHR). As a glycosylated protein, its biological activity and stability are influenced by its carbohydrate moieties.

Application

Thyroid stimulating hormone has been used in:

• Studies of thyroid function and regulation
• Cell-based assays involving TSH receptor activation
• Endocrine signaling and hormone response studies
• Assays evaluating thyroid hormone biosynthesis

Biochem/physiol Actions

TSH binds to the TSH receptor (TSHR) on thyroid follicular cells, activating cAMP-dependent signaling pathways that regulate thyroid hormone synthesis and secretion (T3 and T4). It plays a central role in maintaining metabolic homeostasis and regulating growth and development.

Physical form

Lyophilized from 10mM KPB (pH 8.0), 0.150M NaCl

Preparation Note

It is recommended that the powder be reconstituted in physiological saline (PH7.0)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids