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T8944
Topoisomerase II α human
(Single band on SDS-PAGE), liquid
Synonym(e):
Topoisomerase II alpha, TOPO® II, p170
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Unterstützung erhaltenQuality Segment
form
liquid
mol wt
170 kDa
UniProt accession no.
storage temp.
−70°C
Gene Information
human ... TOP2A(7153)
General description
Topoisomerase II α (TopoIIα) is a gene product with conserved catalytic activities and it promotes the progression of DNA damage. The α isoform is present in proliferating cells.
Topoisomerase II α is encoded by TOP2A gene, which is located on 17q21.2 in the human chromosome. It is essential for controlling the topological state of DNA by reversibly breaking the DNA strands during replication, recombination and transcription. TOP2A expression increases at late S phase and during G2/M of the cell cycle and decreases after mitosis. Polymorphism with TOP2A causes chromosome instability and tumorigenesis. TOP2A causes tumor proliferation and invasiveness in various cancer types like breast cancer, ovarian cancer and prostate cancer.
Application
Biochem/physiol Actions
Used to study DNA structure and topology.
Physical form
Buffered aqueous glycerol solution, containing Trizma buffer (pH 7.7). Other components are present in the solution, and lot-specific information on these components may be obtained from Technical Service.
Preparation Note
Recombinant enzyme overexpressed in a proprietary eukaryotic cell line.
Other Notes
One unit will decatenate 0.2 μg of kinetoplast DNA in 30 minutes at 37°C.
Legal Information
TOPO is a registered trademark of Life Technologies
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Dieser Artikel | |||
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| description (Single band on SDS-PAGE), liquid | description clone KiS1, Chemicon®, from mouse | description Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2 | description clone RM394, affinity purified immunoglobulin |
| Gene Information human ... TOP2A(7153) | Gene Information human ... TOP2A(7153) | Gene Information human ... TOP2A(7153) | Gene Information human ... TOP2A(7153) |
| form liquid | form - | form buffered aqueous glycerol solution | form liquid |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| mol wt 170 kDa | mol wt - | mol wt - | mol wt - |
| storage temp. −70°C | storage temp. - | storage temp. −20°C | storage temp. −20°C |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level - |
Lagerklasse
12 - Non Combustible Liquids
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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