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Merck

Patients' perceptions of topical treatments of actinic keratosis.

The Journal of dermatological treatment (2012-12-12)
Solveig Esmann, Gregor B E Jemec
ZUSAMMENFASSUNG

In recent years, a number of topical treatments suitable for field-directed therapy of actinic keratosis (AK) have been developed. Non-surgical treatment of AK however requires strict adherence by patients. Patients' views on the different possible topical treatments are therefore relevant to the choice of treatment. The aim of the study was to disclose the "silent perspectives" by focusing on user experiences and individual perspectives on topical treatment. Telephone interviews and face-to-face interviews were conducted with patients having had treatment with one or more of the following: imiquimod 5%, diclofenac sodium gel 3%, 5-fluorouracil (5-FU) cream 5% or photodynamic therapy. 24 patients with AK were interviewed. Experiences of pain, discharging ulcers and efficiency of the treatment were of major importance. There was a general focus on appearance, social contacts and leisure time, although this appeared to be of lesser importance. Patients' perception of treatment instructions identified a risk of misunderstandings. Patients are primarily concerned with therapeutic efficiency. Pain and ulcers are central indicators, but appearance, social contacts and leisure time can also be considered as additional indicators of satisfaction. A firm focus on patient instruction is suggested.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
5-Fluorouracil, ≥99% (HPLC), powder
Sigma-Aldrich
Diclofenac Natriumsalz
Supelco
Diclofenac Natriumsalz, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Imiquimod, ≥98% (HPLC), solid
USP
Diclofenacnatrium, United States Pharmacopeia (USP) Reference Standard
Supelco
Diclofenac Natriumsalz, analytical standard
Diclofenac für die Systemeignung, European Pharmacopoeia (EP) Reference Standard
Supelco
5-Fluorouracil, analytical standard
Diclofenac-Natrium, European Pharmacopoeia (EP) Reference Standard
Supelco
Fluorouracil, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Fluorouracil, meets USP testing specifications
Diclofenac-Kalium, European Pharmacopoeia (EP) Reference Standard
Fluorouracil, European Pharmacopoeia (EP) Reference Standard