This product is offered in a powdered format. Unless otherwise stated, this product is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals.
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I5159
Imiquimod
≥98% (HPLC), solid, caspase 3 activator
Synonym(e):
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
200 mg | Warenkorb auf Verfügbarkeit prüfen | € 209,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C14H16N4
CAS-Nummer:
Molekulargewicht:
240.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Technischer Dienst
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Unterstützung erhaltenProduktname
Imiquimod, ≥98% (HPLC), solid
Quality Segment
assay
≥98% (HPLC)
form
solid
solubility
H2O: <2 mg/mL, DMSO: 4 mg/mL (warming to 60 °C for 15 minutes)
SMILES string
CC(C)Cn1cnc2c(N)nc3ccccc3c12
InChI
1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
InChI key
DOUYETYNHWVLEO-UHFFFAOYSA-N
Gene Information
human ... TLR7(51284)
General description
Imiquimod is a toll-like receptor (TLR)-7/8 agonist.
Application
Imiquimod has been used as TLR7 agonist for TLR7 agonist enhancement studies. It has also been used as an NLR family, pyrin domain containing 3 (NLRP3) stimulant to treat NLRP3-FL-Btn and FLAG-ASC-FL.
Biochem/physiol Actions
Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo in basal cell carcinoma. Its anti-tumor activity is related to the induction of apoptosis. Imiquimod has anti-angiogenic, anti-inflammatory, anti-viral activities. Imiquimod also acts as an immune response modulator inducing the secretion of various cytokines and chemokines.
Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo and acts as an immunomodulator with anti-viral and anti-inflammatory perties.
Imiquimod helps to induce the innate cutaneous immunity and the cellular arm of the adaptive immune response.
Features and Benefits
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Dieser Artikel | |||
|---|---|---|---|
| description ≥98% (HPLC), solid | description United States Pharmacopeia (USP) Reference Standard | description Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 500 mg | description An imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties. |
| assay ≥98% (HPLC) | assay - | assay - | assay ≥98% (HPLC) |
| form solid | form - | form solid | form solid |
| Quality Level 100 | Quality Level - | Quality Level 300 | Quality Level 100 |
| solubility DMSO: 4 mg/mL (warming to 60 °C for 15 minutes), H2O: <2 mg/mL | solubility - | solubility - | solubility DMSO: 3 mg/mL |
| Gene Information human ... TLR7(51284) | Gene Information human ... TLR7(51284) | Gene Information - | Gene Information - |
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Signalwort
Danger
Gefahrencodes
Sicherheitshinweise
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
PSA (Persönliche Schutzausrüstung)
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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