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  • Preventing intraperitoneal adhesions with linezolid and hyaluronic acid/carboxymethylcellulose: a comparative study in cecal abrasion model.

Preventing intraperitoneal adhesions with linezolid and hyaluronic acid/carboxymethylcellulose: a comparative study in cecal abrasion model.

American journal of surgery (2014-05-13)
Kasim Caglayan, Bulent Gungor, Hamza Cinar, Nilsen Y Erdogan, Bulent Koca
PMID24814308
ZUSAMMENFASSUNG

We aimed to compare the effectiveness of linezolid in preventing intraperitoneal adhesions with hyaluronic acid + carboxymethylcellulose (Seprafilm). Thirty rats were divided randomly into 3 groups: Group I (control), untreated; Group II (Seprafilm); and Group III (linezolid). All rats were sacrificed on the 14th day after surgery. Macroscopic adhesion, inflammation, and fibrosis were evaluated. The multiple comparisons between groups showed a statistically significant difference for adhesion. There were statistically significant differences between Group I and II and I and III, but no statistically significant difference between Group II and III. The multiple comparisons between the groups showed a statistically significant difference for inflammation and fibrosis. For inflammation and fibrosis, there was a statistically significant difference between Group I and II and I and III, but no statistically significant difference between Group II and III. The efficiency of linezolid in reducing the formation of intraperitoneal adhesions was statistically significant compared with the control group.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung
53747
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., bacterial glycosaminoglycan polysaccharide
C4888
Sigma-Aldrich
Carboxymethylcellulose Natriumsalz, Medium viscosity
C5678
Sigma-Aldrich
Carboxymethylcellulose Natriumsalz, low viscosity
419273
Sigma-Aldrich
Natriumcarboxymethylcellulose Natriumsalz, viscosity 50-200 cP , c=4% H2O at 25­°C
C5013
Sigma-Aldrich
Carboxymethylcellulose Natriumsalz, High viscosity
419338
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Natriumcarboxymethylcellulose Natriumsalz, viscosity 2500-6000 cP 
419303
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Natriumcarboxymethylcellulose Natriumsalz, average Mw ~250,000, degree of substitution 0.9
H5388
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Hyaluronsäure Natriumsalz aus rooster comb, avian glycosaminoglycan polysaccharide
419281
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Natriumcarboxymethylcellulose Natriumsalz, average Mw ~250,000, degree of substitution 1.2
419311
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Natriumcarboxymethylcellulose Natriumsalz, average Mw ~250,000, degree of substitution 0.7
21902
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Carboxymethylcellulose Natriumsalz, medium viscosity
H7630
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Hyaluronsäure Natriumsalz aus Rinderaugen-Glaskörper
40583
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Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 8,000-15,000
21904
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Carboxymethylcellulose Natriumsalz, ultra high viscosity, highly purified
53163
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Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 750,000-1,000,000
C9481
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Carboxymethylcellulose Natriumsalz, meets USP testing specifications, Medium viscosity
X1126
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Xylazin, ≥99%
41897
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Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 1,000,000-1,250,000
H9390
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Hyaluronic acid sodium salt from Streptococcus zooepidemicus, bacterial glycosaminoglycan polysaccharide
63357
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Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 1,500,000-1,750,000
75043
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Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 130,000-150,000
42686
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Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 30,000-50,000
75044
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Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 150,000-300,000
73641
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Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 2,000,000-2,400,000
49775
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00941
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Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 300,000-500,000
94137
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Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 10,000-30,000
75574
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Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 500,000-750,000
51967
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Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 2,000,000-2,200,000
08185
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Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 50,000-90,000