Direkt zum Inhalt
Merck
  • Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid.

Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid.

Nature materials (2014-08-05)
Anirudha Singh, Michael Corvelli, Shimon A Unterman, Kevin A Wepasnick, Peter McDonnell, Jennifer H Elisseeff
PMID25087069
ZUSAMMENFASSUNG

Lubrication is key for the efficient function of devices and tissues with moving surfaces, such as articulating joints, ocular surfaces and the lungs. Indeed, lubrication dysfunction leads to increased friction and degeneration of these systems. Here, we present a polymer-peptide surface coating platform to non-covalently bind hyaluronic acid (HA), a natural lubricant in the body. Tissue surfaces treated with the HA-binding system exhibited higher lubricity values, and in vivo were able to retain HA in the articular joint and to bind ocular tissue surfaces. Biomaterials-mediated strategies that locally bind and concentrate HA could provide physical and biological benefits when used to treat tissue-lubricating dysfunction and to coat medical devices.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung
53747
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., bacterial glycosaminoglycan polysaccharide
H5388
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus rooster comb, avian glycosaminoglycan polysaccharide
H7630
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Rinderaugen-Glaskörper
40583
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 8,000-15,000
53163
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 750,000-1,000,000
41897
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 1,000,000-1,250,000
H9390
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus zooepidemicus, bacterial glycosaminoglycan polysaccharide
63357
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 1,500,000-1,750,000
75043
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 130,000-150,000
42686
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 30,000-50,000
75044
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 150,000-300,000
73641
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 2,000,000-2,400,000
49775
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 1,200
00941
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 300,000-500,000
94137
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 10,000-30,000
75574
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 500,000-750,000
51967
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 2,000,000-2,200,000
08185
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 50,000-90,000
97616
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 15,000-30,000
80486
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 1,250,000-1,500,000
75046
Sigma-Aldrich
Hyaluronsäure Natriumsalz aus Streptococcus equi sp., mol wt 90,000-110,000