Composition controlled synthesis of PCL-PEG Janus nanoparticles: magnetite nanoparticles prepared from one-pot photo-click reaction.

Composition controlled synthesis of PCL-PEG Janus nanoparticles: magnetite nanoparticles prepared from one-pot photo-click reaction.

Nanoscale (2015-02-11)

S Khoee, Y Bagheri, A Hashemi

ZUSAMMENFASSUNG

The aim of this study is to investigate the effect of polymer nature on the morphology of synthesized nanoparticles. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared by co-precipitation method and then reacted with (3-mercaptopropyl) trimethoxysilane to obtain thiol-decorated SPIONs. Acrylated poly(caprolactone) and methoxy poly(ethylene glycol) were prepared, and then "thiol-ene click" reaction was performed under UV irradiation to attach two types of polymers on the surface of magnetite nanoparticles via the "photo-click" reaction method. Computational modelling was used for the prediction of the self-assembly of polymers on the surface of SPIONs, which determines the morphology of polymer coated nanoparticles.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

258148

Sigma-Aldrich

Salzsäure, ACS reagent, 37%

319937

Sigma-Aldrich

N,N-Dimethylformamid, ACS reagent, ≥99.8%

270547

Sigma-Aldrich

N,N-Dimethylformamid, suitable for HPLC, ≥99.9%

227056

Sigma-Aldrich

N,N-Dimethylformamid, anhydrous, 99.8%

320331

Sigma-Aldrich

Salzsäure, ACS reagent, 37%

345547

Sigma-Aldrich

Chlorwasserstoff -Lösung, 4.0 M in dioxane

471283

Sigma-Aldrich

Triethylamin, ≥99.5%

F8775

Sigma-Aldrich

Formaldehyd -Lösung, Molecular Biology, 36.5-38% in H₂O

T8154

Sigma-Aldrich

Trypanblau -Lösung, 0.4%, liquid, sterile-filtered, suitable for cell culture

H9892

Sigma-Aldrich

Salzsäure -Lösung, 1.0 N, BioReagent, suitable for cell culture

252549

Sigma-Aldrich

Formaldehyd -Lösung, ACS reagent, 37 wt. % in H₂O, contains 10-15% Methanol as stabilizer (to prevent polymerization)

F1635

SAFC

Formaldehyd -Lösung, contains 10-15% methanol as stabilizer, 37 wt. % in H₂O

07102

Sigma-Aldrich

Salzsäure, meets analytical specification of Ph. Eur., BP, NF, fuming, 36.5-38%

339253

Sigma-Aldrich

Salzsäure, 37 wt. % in H₂O, 99.999% trace metals basis

T0886

Sigma-Aldrich

Triethylamin, ≥99%

455180

Sigma-Aldrich

Chlorwasserstoff -Lösung, 2.0 M in diethyl ether

D158550

Sigma-Aldrich

N,N-Dimethylformamid, ReagentPlus^®, ≥99%

90335

Sigma-Aldrich

Triethylamin, BioUltra, ≥99.5% (GC)

90340

Sigma-Aldrich

Triethylamin, puriss. p.a., ≥99.5% (GC)

H1758

Sigma-Aldrich

Salzsäure, 36.5-38.0%, BioReagent, Molecular Biology

A24109

Sigma-Aldrich

Acryloylchlorid, ≥97%, contains ~400 ppm phenothiazine as stabilizer

D4551

Sigma-Aldrich

N,N-Dimethylformamid, Molecular Biology, ≥99%

2104

Supelco

Salzsäure -Lösung, volumetric, 0.1 M HCl (0.1N), endotoxin free

47608

Sigma-Aldrich

Formaldehyd -Lösung, Molecular Biology, BioReagent, ≥36.0% in H₂O (T)

T6146

Sigma-Aldrich

Trypanblau, powder, BioReagent, suitable for cell culture

494488

Sigma-Aldrich

N,N-Dimethylformamid, biotech. grade, ≥99.9%

294837

Sigma-Aldrich

Chlorwasserstoff -Lösung, 1.0 M in diethyl ether

84429

Sigma-Aldrich

Salzsäure -Lösung, ~6 M in H₂O, for amino acid analysis

93595

Sigma-Aldrich

Trypanblau -Lösung, 0.4%, suitable for microscopy

15512

Sigma-Aldrich

Formaldehyd -Lösung, meets analytical specification of USP, ≥34.5 wt. %