- Peripheral interleukin-6 promotes resilience versus susceptibility to inescapable electric stress.
Peripheral interleukin-6 promotes resilience versus susceptibility to inescapable electric stress.
Acta neuropsychiatrica (2015-05-29)
Chun Yang, Yukihiko Shirayama, Ji-Chun Zhang, Qian Ren, Kenji Hashimoto
PMID26017899
ZUSAMMENFASSUNG
Accumulating evidences suggest that pro-inflammatory cytokines such as interleukin-6 (IL-6) play a role in the pathophysiology of depression. In the learned helplessness (LH) paradigm, ~35% rats are resilient to inescapable stress. Levels of IL-6 in the serum and medial prefrontal cortex (mPFC) of LH rats (susceptible) and non-LH rats (resilience) were measured using enzyme-linked immunosorbent assay and western blot analysis, respectively. Serum levels of IL-6 in the LH rats were significantly higher than those of control and non-LH rats. In contrast, tissue levels of IL-6 in the mPFC were not different among three groups. The results suggest that peripheral IL-6 may contribute to resilience versus susceptibility to inescapable stress.
MATERIALIEN
Produktnummer
Marke
Produktbeschreibung
Sigma-Aldrich
Natriumdodecylsulfat, BioReagent, suitable for electrophoresis, Molecular Biology, ≥98.5% (GC)
Sigma-Aldrich
2-Mercaptoethanol, Molecular Biology, suitable for electrophoresis, suitable for cell culture, BioReagent, 99% (GC/titration)
Sigma-Aldrich
Glycerin, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for electrophoresis, ≥99% (GC)
Supelco
Natriumdodecylsulfat, dust-free pellets, suitable for electrophoresis, Molecular Biology, ≥99.0% (GC)