G7403

Glycine

≥99% (titration), suitable for electron microscopy, BioXtra

• Synonym(s): Aminoacetic acid, Aminoethanoic acid, Glycocoll
• Linear Formula: NH₂CH₂COOH
• CAS Number: 56-40-6
• Molecular Weight: 75.07
• NACRES: NA.26
• PubChem Substance ID: 24895306
• eCl@ss: 32160406
• UNSPSC Code: 12352209
• EC Number: 200-272-2
• MDL number: MFCD00008131
• Beilstein/REAXYS Number: 635782

Properties

• Product Name: Glycine, BioXtra, ≥99% (titration)
• InChI key: DHMQDGOQFOQNFH-UHFFFAOYSA-N
• InChI: 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• SMILES string: NCC(O)=O
• product line: BioXtra
• assay: ≥99% (titration)
• form: powder
• technique(s): electron microscopy: suitable
• impurities: Insoluble matter, passes filter test
• ign. residue: ≤0.05%
• loss: ≤0.05% loss on drying, HV, 20-26 °C
• color: white
• pKa (25 °C): (1) 2.35, (2) 9.60; 2.35
• mp: 240 °C (dec.) (lit.)
• solubility: 1 M HCl: 1 M, clear, colorless
• anion traces: chloride (Cl^-): ≤0.005%; sulfate (SO₄^2-): ≤0.005%
• cation traces: Al: ≤0.0005%; As: ≤0.00001%; Ba: ≤0.0005%; Bi: ≤0.0005%; Ca: ≤0.001%; Cd: ≤0.0005%; Co: ≤0.0005%; Cr: ≤0.0005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Li: ≤0.0005%; Mg: ≤0.0005%; Mn: ≤0.0005%; Mo: ≤0.0005%; NH₄⁺: ≤0.02%; Na: ≤0.02%; Ni: ≤0.0005%; Pb: ≤0.0005%; Sr: ≤0.0005%; Zn: ≤0.0005%
• absorption: ≤0.04 at 260 in 1 M HCl at 1 M; ≤0.04 at 280 in 1 M HCl at 1 M
• UV absorption: λ: 260 nm A_max: ≤0.04; λ: 260 nm A_max: 0.003; λ: 260 nm A_max: 0.006
• Quality Level: 200
• Gene Information: rat ... Grin2a(24409)

Description

Application

Glycine has been used to quench unreacted aldehyde during sample (nuclei) preparation for scanning electron microscope.[1] It has also been used for sample fixation in the process of immunolabeling.[2]

Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Glycine is a non-essential amino acid.[3] Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors.[4] Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.[3]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)