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Merck

03-0145-00

SMC® Amyloid Beta 1-40 High Sensitivity Immunoassay Kit

Synonyme(s) :

Abeta 1-40 immunoassay kit, Abeta 40 Single Molecule Counting kit, Abeta 40 immunoassay kit, Abeta 40 ultra-sensitive immunoassay

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96 WELLS

1 090,00 €

1 090,00 €

Date d'expédition estimée le26 décembre 2025Détails

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A propos de cet article

Code UNSPSC :
12161503
eCl@ss :
32161000
Nomenclature NACRES :
NA.84

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Niveau de qualité

200

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Cet article
03-0146-00EZHS4003-0188-00
SMC® Amyloid Beta 1-40 High Sensitivity Immunoassay Kit

Millipore

03-0145-00

SMC® Amyloid Beta 1-40 High Sensitivity Immunoassay Kit

SMC® Amyloid Beta 42 High Sensitivity Immunoassay Kit

Millipore

03-0146-00

SMC® Amyloid Beta 42 High Sensitivity Immunoassay Kit

High Sensitivity Human Amyloid β40 ELISA This High Sensitivity Human Amyloid β40 ELISA is used to measure & quantify Amyloid β40 levels in Neuroscience research.

Millipore

EZHS40

High Sensitivity Human Amyloid β40 ELISA

Kit haute sensibilité pour la phospho-α-synucléine humaine (S129) SMC®

Millipore

03-0188-00

Kit haute sensibilité pour la phospho-α-synucléine humaine (S129) SMC®

technique(s)

ELISA: suitable, single molecule counting: suitable

technique(s)

ELISA: suitable, single molecule counting: suitable

technique(s)

ELISA: suitable

technique(s)

single molecule counting: suitable

manufacturer/tradename

SMC®

manufacturer/tradename

SMC®

manufacturer/tradename

-

manufacturer/tradename

SMC®

assay range

sensitivity: 5.86 pg/mL
(lower limit of quantification)

assay range

sensitivity: 0.98 pg/mL
(lower limit of quantification), inter-assay cv: <20%
intra-assay cv: <15%
standard curve range: 0.24-250 pg/mL

assay range

sensitivity: 6.0 pg/mL
(50 μl sample size), standard curve range: 16-500 pg/mL

assay range

sensitivity: 0.1 pg/mL
(Lower Limit of Quantification), inter-assay cv: 7%
intra-assay cv: 6%
(five normal plasma samples run in triplicate by 3 different operators on 3 different days.)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

-

Description générale

Amyloid Beta 1-40 (Aβ1-40) is a peptide that arises from the proteolytic cleavage of the amyloid precursor protein (APP), a transmembrane protein thought to be involved in neuronal development and function. Aβ1-40 is one of the most common isoforms generated from APP, alongside Aβ1-42, which is more toxic and associated with the formation of amyloid plaques in neurodegenerative diseases.
Aβ1-40 plays a significant role in the pathophysiology of Alzheimer′s disease. Elevated levels of Aβ1-40 in the brain can contribute to neuroinflammation and neuronal damage, disrupting cell signaling and promoting the formation of amyloid plaques. These plaques are characteristic of AD and are believed to trigger a cascade of neurodegenerative processes, leading to cognitive decline and other symptoms associated with the disease. Understanding the function and implications of Aβ1-40 is essential for developing effective diagnostic tools and therapeutic strategies aimed at mitigating its harmful effects in neurodegenerative conditions.

Application

Neuroscience/Neurological Disorders/Signaling

Actions biochimiques/physiologiques

Although Amyloid Beta 40 was detectable in mouse and rat samples, the assay has not been verified for these species.

Caractéristiques et avantages

  • Exceptional Sensitivity: Detects Amyloid Beta 1-40 at femtogram levels, significantly outperforming conventional ELISA methods.
  • Wider Dynamic Range: Minimizes background interference to deliver clearer signals and improved assay reliability.
  • Optimized Workflow Efficiency: Automation-compatible reagents streamline lab processes and reduce manual intervention.
  • Experienced Technical Support: Supported by skilled field scientists and technical teams with expertise in SMC® assays.

Conditionnement

96 well assay

Remarque sur l'analyse

Neuroscience Neurological Disorders Neurodegenerative Diseases Alzheimer′s Disease

Informations légales

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

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Chia-Liang Tsai et al.
Journal of clinical medicine, 8(10) (2019-10-09)
Nondemented people with a family history of Alzheimer's disease (ADFH) and the ApoE-4 allele have been demonstrated to show a trend for a higher probability of cognitive decline and aberrant levels of cognitive-related biomarkers. However, the potential interactive effects on

Protocoles

Protein Determination by the Warburg-Christian Method

To determine protein content, the Warburg-Christian method refers to measuring protein samples at 280 nm using a spectrophotometer.

Contenu apparenté

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Ultrasensitive Immunassays für die Neurologie | SMC®-Technologie

Nutzen Sie die Leistungsfähigkeit von hochsensitiven Immunassays mit SMC®-Technologie (Einzelmolekül-Zählung) in der neurowissenschaftlichen Forschung für die präzise Messung von Proteinanalyten als neurologische Schlüsselmarker für Gesundheits- und Krankheitszustände mithilfe der leistungsstarken SMCxPRO® Nachweis-Plattform. Analysieren Sie neurowissenschaftliche Biomarker wie NF-L, GFAP, Tau-Protein, Beta-Amyloid und weitere.

Protein Quantitation

Protein quantification methods, reagents, and immunoassay technology for accurately measuring the protein concentrations in a variety of samples.

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