05-1087

Anti-phospho-IRS1 (Ser307 mouse/ Ser312 human) Antibody, clone 24.6.2

Name: Anti-phospho-IRS1 (Ser307 mouse/ Ser312 human) Antibody, clone 24.6.2
Brand: MM
Price: 529 EUR
Availability: InStock

clone 24.6.2, from mouse

Synonyme(s) :

insulin receptor substrate 1

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100 μG

529,00 €

Date d'expédition estimée le10 décembre 2025Détails

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A propos de cet article

Code UNSPSC :

12352203

eCl@ss :

32160702

Nomenclature NACRES :

NA.41

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Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

24.6.2, monoclonal

Espèces réactives

bovine, pig, mouse, monkey, canine, rat, human

Technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotype

IgG2aκ

Numéro d'accès NCBI

NP_005535.1

Numéro d'accès UniProt

P35568

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

phosphorylation (pSer307 )

Informations sur le gène

bovine ... Irs1(538598)
dog ... Irs1(486148)
human ... IRS1(3667)
mouse ... Irs1(16367)
pig ... Irs1(100512686)
rat ... Irs1(25467)
rhesus monkey ... Irs1(707870)

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Cet article	05-1086	05-1085	05-784R
Sigma-Aldrich 05-1087 Anti-phospho-IRS1 (Ser307 mouse/ Ser312 human) Antibody, clone 24.6.2	Sigma-Aldrich 05-1086 Anti-phospho-IRS1 (Ser302 mouse/ Ser307 human) Antibody, clone 8.1.2	Sigma-Aldrich 05-1085 Anti-IRS1 Antibody, clone 4.2.2	Sigma-Aldrich 05-784R Anti-IRS1 Antibody, clone 58-10C-31, rabbit monoclonal
biological source mouse	biological source mouse	biological source mouse	biological source rabbit
clone 24.6.2, monoclonal	clone 8.1.2, monoclonal	clone 4.2.2, monoclonal	clone 58-10C-31, monoclonal
species reactivity bovine, pig, mouse, monkey, canine, rat, human	species reactivity bovine, pig, canine, monkey, human, rat, mouse	species reactivity pig, canine, human, mouse, rat, monkey, bovine	species reactivity human, rat, mouse
antibody form purified antibody	antibody form purified antibody	antibody form purified antibody	antibody form purified immunoglobulin
UniProt accession no. P35568	UniProt accession no. P35568	UniProt accession no. P35568	UniProt accession no. P35570
technique(s) immunocytochemistry: suitable, immunoprecipitation (IP): suitable, immunofluorescence: suitable, western blot: suitable	technique(s) immunofluorescence: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable	technique(s) immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable	technique(s) immunoprecipitation (IP): suitable, western blot: suitable

Description générale

IRS1 (Insulin Receptor Substrate 1) transmits insulin signals via metabolic and mitogenic pathways. IRS1 is heavily phosphorylated on both serine and tyrosine residues. These phosphorylated tyrosines enable IRS to act as a docking protein that binds SH2 domains of such proteins as PI3 Kinase (phosphatidylinositol 3-kinase) and GRB2, resulting in activation. Over expression and phosphorylation of serine is associated with insulin resistance and breast cancer. Some of the more notable phosphorylation sites are Ser302 that is phosphorylated following insulin stimulation. Ser307, phosphorylated by JNK and IKK, is a key regulatory site that appears to disrupt the IRS1/IR interaction and inhibits insulin-mediated activation of the PI3 kinase and MAPK pathways, and Ser636/639 that is known to be phosphorylated by p70S6K downstream of mTOR and acts as a negative feedback loop.

Env. 185 kDa

Immunogène

Synthetic peptide corresponding to amino acids surrounding phosphorylated Ser307 of mouse IRS1.

Application

This Anti-phospho-IRS1 (Ser307 mouse/ Ser312 human) Antibody, clone 24.6.2 is validated for use in WB, IP, IC, IF for the detection of phospho-IRS1 (Ser307 mouse/ Ser312 human).

Actions biochimiques/physiologiques

Predicted to cross-react with many other species based on 100% sequence homology with immunogen.

This antibody recognizes IRS1 phosphorylated at Ser307 (mouse) and Ser312 (human).

Forme physique

Format : Produit purifié

Remarque sur l'analyse

1:1,000 dilution of this antibody was used to detect IRS1 in IRS/IR transfected CHO -/+ Calyculin A/ Okadaic Acid-treated cell lysate.

Autres remarques

Concentration : pour connaître la concentration spécifique du lot, voir le certificat d'analyse.

Remplace le(s) produit(s) suivant(s) : 07-247

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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