07-095

Anti-PP2A-methylesterase/PME-1 Antibody

Name: Anti-PP2A-methylesterase/PME-1 Antibody
Brand: MM
Price: 460 EUR
Availability: InStock

Upstate^®, from rabbit

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200 μG

460,00 €

Date d'expédition estimée le15 janvier 2026Détails

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A propos de cet article

Code UNSPSC :

12352203

eCl@ss :

32160702

Nomenclature NACRES :

NA.41

Principaux documents

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Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

human, rat, mouse

Fabricant/nom de marque

Upstate^®

Technique(s)

western blot: suitable

Isotype

IgG

Numéro d'accès NCBI

NM_016147

Numéro d'accès UniProt

Q9Y570

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... PPME1(51400)

Catégories apparentées

Anticorps - Primaires, secondaires et monoclonaux recombinants

Anticorps primaires

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Cet article	06-222	05-592	07-250
Sigma-Aldrich 07-095 Anti-PP2A-methylesterase/PME-1 Antibody	Sigma-Aldrich 06-222 Anti-PP2A Antibody, C subunit	Sigma-Aldrich 05-592 Anti-PP2A Antibody, B subunit, clone 2G9	Sigma-Aldrich 07-250 Anti-PP2A Antibody, A subunit
biological source rabbit	biological source rabbit	biological source mouse	biological source rabbit
clone polyclonal	clone polyclonal	clone 2G9, monoclonal	clone polyclonal
species reactivity human, rat, mouse	species reactivity mouse, human, rabbit, rat	species reactivity rat, bovine, mouse, Xenopus, rabbit, pig, human	species reactivity human, mouse, Xenopus, pig, rat
antibody form purified immunoglobulin	antibody form serum	antibody form ascites fluid	antibody form affinity isolated antibody
shipped in dry ice	shipped in dry ice	shipped in wet ice	shipped in dry ice
Gene Information human ... PPME1(51400)	Gene Information human ... PPP2CA(5515)	Gene Information human ... PPP2CA(5515)	Gene Information human ... PPP2R1A(5518)

Description générale

44kDa

Immunogène

A mixture of two nickel agarose-purified, His6-tagged, bacterial expressed human Protein Phosphatase Methylesterase-1 (PME-1) fragments (residues 225-302 and 277-387). These two fragments represent the carboxyl-terminal portion of the protein.

Application

Research Category
Signaling

Neuroscience

Research Sub Category
Neurotransmitters & Receptors

Neurodegenerative Diseases

This Anti-PP2A-methylesterase/PME-1 Antibody is validated for use in IP, WB for the detection of PP2A-methylesterase/PME-1.

Actions biochimiques/physiologiques

Protein Phosphatase Methylesterase-1

Forme physique

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%

Format: Purified

Protein A chromatography

Notes préparatoires

2 years at -20°C

Remarque sur l'analyse

Control
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.

routinely evaluated by immunoblot on RIPA lysates from mouse 3T3 fibroblasts

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Single-pot enzymatic synthesis of Dicer-substrate siRNAs.

Guiley, KZ; Pratt, AJ; MacRae, IJ

Nucleic Acids Research null

Leucine Carboxyl Methyltransferase 1 Overexpression Protects Against Cognitive and Electrophysiological Impairments in Tg2576 APP Transgenic Mice.

Madhumathi Gnanaprakash et al.

Journal of Alzheimer's disease : JAD, 79(4), 1813-1829 (2021-01-19)

The serine/threonine protein phosphatase, PP2A, is thought to play a central role in the molecular pathogenesis of Alzheimer's disease (AD), and the activity and substrate specificity of PP2A is regulated, in part, through methylation and demethylation of its catalytic subunit.

NLRP3 inflammasome activation drives tau pathology.

Christina Ising et al.

Nature, 575(7784), 669-673 (2019-11-22)

Alzheimer's disease is characterized by the accumulation of amyloid-beta in plaques, aggregation of hyperphosphorylated tau in neurofibrillary tangles and neuroinflammation, together resulting in neurodegeneration and cognitive decline1. The NLRP3 inflammasome assembles inside of microglia on activation, leading to increased cleavage

Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis.

Ha Yin Lee et al.

Science signaling, 11(512) (2018-01-11)

Cancer cells increase glucose metabolism to support aerobic glycolysis. However, only some cancer cells are acutely sensitive to glucose withdrawal, and the underlying mechanism of this selective sensitivity is unclear. We showed that glucose deprivation initiates a cell death pathway

Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.

Kesava Asam et al.

PloS one, 12(12), e0189413-e0189413 (2017-12-19)

Soluble forms of oligomeric beta-amyloid (Aβ) are thought to play a central role in Alzheimer's disease (AD). Transgenic manipulation of methylation of the serine/threonine protein phosphatase, PP2A, was recently shown to alter the sensitivity of mice to AD-related impairments resulting

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