1.37156

Pyridoxine hydrochloride

EMPROVE^® EXPERT, Ph. Eur., BP, JP, USP, FCC

• Synonyme(s) : PN HCl, Pyridoxol hydrochloride
• Formule empirique (notation de Hill) : C₈H₁₁NO₃ · HCl
• Numéro CAS: 58-56-0
• Poids moléculaire : 205.64
• Beilstein: 3632435
• Numéro MDL: MFCD00012807
• Code UNSPSC : 41116107

Propriétés

• Agence: BP; JP; Ph. Eur.; USP
• Niveau de qualité: 500
• Conformité réglementaire: FCC
• Gamme de produits: EMPROVE^® EXPERT
• Pf: 214-215 °C (lit.)
• Application(s): clinical nutrition; liquid formulation; parenterals; pharmaceutical; vitamins, nutraceuticals, and natural products
• Température de stockage: 15-25°C
• Chaîne SMILES: Cl[H].Cc1ncc(CO)c(CO)c1O
• InChI: 1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H
• Clé InChI: ZUFQODAHGAHPFQ-UHFFFAOYSA-N

Description

Description générale

For protein-based therapeutics, such as monoclonal antibodies (mAbs) or plasma derived proteins, often highly concentrated protein formulations are required to meet intended dosing regimens. However, this usually comes with elevated viscosities and presents a challenge in the manufacturing process and final formulation. Our Viscosity Reduction Excipient Platform reduces the viscosity and helps overcome challenges associated with highly concentrated protein solutions.

As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation.

Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

The Viscosity Reduction Platform is based on the combination of two new excipients, one amino acid component with one anionic component, that together can better reduce protein viscosity beyond levels achieved with single excipients. Also, combining the two components enables a balance of viscosity reduction and protein stabilization. Pyridoxine hydrochloride Emprove^® Expert is part of this new proprietary technology platform. Also, Pyridoxine hydrochloride (Vitamin B6) is used in clinical nutrition for treatment of vitamin B6 deficiency, anemia, mental retardation, Parkinson′s syndrome, gestational diabetes, tetanus and atherosclerosis.

Conditionnement

1.37156.0100 / 100g / PE bottle
1.37156.1000 / 1kg / PE bottle
1.37156.9012 / 12kg / PE bucket

Informations légales

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H318
• Conseils de prudence: P280 - P305 + P351 + P338
• Classification des risques: Eye Dam. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable