105945

Phenolphthalein

ACS reagent

• Synonyme(s) : 3,3-Bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone
• Formule empirique (notation de Hill) : C₂₀H₁₄O₄
• Numéro CAS: 77-09-8
• Poids moléculaire : 318.32
• Numéro C.I. (Colour Index): 764
• Beilstein: 284423
• Numéro CE : 201-004-7
• Numéro MDL: MFCD00005913
• Code UNSPSC : 12171500
• ID de substance PubChem : 24846716
• Nomenclature NACRES : NA.47

Propriétés

• Qualité: ACS reagent
• Niveau de qualité: 200
• Forme: powder
• Technique(s): titration: suitable
• visual transition interval: 8.0-10, colorless to red
• Pf: 261-263 °C (lit.)
• Solubilité: acetone: soluble
• Densité: 1.27 g/cm³ at 32 °C
• λmax: 374 nm (2nd); 552 nm
• Application(s): diagnostic assay manufacturing; hematology; histology
• Température de stockage: room temp
• Chaîne SMILES: Oc1ccc(cc1)C2(OC(=O)c3ccccc23)c4ccc(O)cc4
• InChI: 1S/C20H14O4/c21-15-9-5-13(6-10-15)20(14-7-11-16(22)12-8-14)18-4-2-1-3-17(18)19(23)24-20/h1-12,21-22H
• Clé InChI: KJFMBFZCATUALV-UHFFFAOYSA-N

Description

Description générale

Phenolphthalein is an indicator for acid-base titration reactions.[1] It changes from colorless to violet-red between pH 8.3-9.8, it is red in extremely acidic solutions, and colorless in extremely alkaline solutions.[2]

It is present as a nonionic, lipophilic lactone in aqueous neutral solutions. It exists as a hydrophilic dianion in alkaline solutions.

Application

Phenolphthalein has been commonly used as an indicator in the fields of biology and medicine. Its applications include:

• the development of novel technique to monitor the vacuum freeze-drying process[3]
• the determination of the depth of carbonation in concrete[4]
• the utilization of liquid marbles to sense gaseous environmental components
• the estimation of total acidity in vinegar
• the assessment of sodium hydroxide penetration into potatoes following chemical peeling
• as a model organic compound in the evaluation of the capture efficiency of various cyclodextrin constructs such as nanofiber-CD

Actions biochimiques/physiologiques

Phenolphthalein is colorless in acidic solutions and turns pink in basic solutions.

Phenolphthalein undergoes structural modification when there is a change in pH or in the structural state of water.[1] It is a nonionic, lipophilic colorless lactone in aqueous neutral solutions and a hydrophilic dianion in alkaline solutions.[2]

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H315,H341,H350,H361f
• Conseils de prudence: P202 - P264 - P280 - P302 + P352 - P308 + P313 - P332 + P313
• Classification des risques: Carc. 1B - Muta. 2 - Repr. 2 - Skin Irrit. 2
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges