G0355000

Glutamic acid

Name: Glutamic acid
Brand: SIAL
Price: 178 EUR

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

L-Glutamic acid, (S)-2-Aminopentanedioic acid, Glu

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A propos de cet article

Formule linéaire :

HO₂CCH₂CH₂CH(NH₂)CO₂H

Numéro CAS:

56-86-0

Poids moléculaire :

147.13

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329799811

MDL number:

MFCD00002634

Beilstein/REAXYS Number:

1723801

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Nom du produit

Glutamic acid, European Pharmacopoeia (EP) Reference Standard

InChI key

WHUUTDBJXJRKMK-VKHMYHEASA-N

SMILES string

N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

grade

pharmaceutical primary standard

API family

glutamic acid

manufacturer/tradename

EDQM

mp

205 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Catégories apparentées

Analytical Reference Materials for Pharma QC

Pharmacopeia & Metrological Institute Standards

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Cet article	PHR1107	G8415	95436
G0355000 Glutamic acid	Supelco PHR1107 L-Glutamic acid	Sigma-Aldrich G8415 L-Glutamic acid	Supelco 95436 L-Glutamic acid
manufacturer/tradename EDQM	manufacturer/tradename -	manufacturer/tradename -	manufacturer/tradename Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard	grade -	grade certified reference material, TraceCERT^®
application(s) pharmaceutical (small molecule)	application(s) cleaning products cosmetics food and beverages personal care pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) cleaning products cosmetics flavors and fragrances food and beverages personal care
format neat	format neat	format -	format neat
API family glutamic acid	API family glutamic acid	API family -	API family -
mp 205 °C (dec.) (lit.)	mp 205 °C (dec.) (lit.)	mp 205 °C (dec.) (lit.)	mp 205 °C (dec.) (lit.)

Application

Glutamic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

related product

Réf. du produit

Description

Tarif

1294976

Glutamic acid, United States Pharmacopeia (USP) Reference Standard

1294987

L-Glutamic acid hydrochloride, United States Pharmacopeia (USP) Reference Standard

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in CaV2.1 knockin migraine mice.

Dania Vecchia et al.

Neurobiology of disease, 69, 225-234 (2014-06-08)

Familial hemiplegic migraine type 1 (FHM1), a monogenic subtype of migraine with aura, is caused by gain-of-function mutations in CaV2.1 (P/Q-type) calcium channels. In FHM1 knockin mice, excitatory neurotransmission at cortical pyramidal cell synapses is enhanced, but inhibitory neurotransmission at

Memory in multiple sclerosis is linked to glutamate concentration in grey matter regions.

Nils Muhlert et al.

Journal of neurology, neurosurgery, and psychiatry, 85(8), 833-839 (2014-01-17)

Glutamate is the principal excitatory neurotransmitter and is involved in normal brain function. Cognitive impairment is common in multiple sclerosis (MS), and understanding its mechanisms is crucial for developing effective treatments. We used structural and metabolic brain imaging to test

Binding of ArgTX-636 in the NMDA receptor ion channel.

Mette H Poulsen et al.

Journal of molecular biology, 427(1), 176-189 (2014-05-28)

The N-methyl-d-aspartate receptors (NMDARs) constitute an important class of ligand-gated cation channels that are involved in the majority of excitatory neurotransmission in the human brain. Compounds that bind in the NMDAR ion channel and act as blockers are use- and

Gamma-fluorinated analogues of glutamic acid and glutamine.

R Dave et al.

Amino acids, 24(3), 245-261 (2003-04-23)

Gamma-fluorinated analogues of glutamic acid and glutamine are compounds of biological interest. Syntheses of such compounds are extensively reviewed in this article. 4-fluoroglutamic acid was prepared as a mixture of racemic diastereomers by Michael reaction, inverse-Michael reaction or by electrophilic

Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway.

Martin D Haustein et al.

Neuron, 82(2), 413-429 (2014-04-20)

The spatiotemporal activities of astrocyte Ca²⁺ signaling in mature neuronal circuits remain unclear. We used genetically encoded Ca²⁺ and glutamate indicators as well as pharmacogenetic and electrical control of neurotransmitter release to explore astrocyte activity in the hippocampal mossy fiber

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