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L9504
D-Luciferin
luminescent, ≥98% (HPLC), powder
Synonyme(s) :
(S)-2-(6-Hydroxy-2-benzothiazolyl)-2-thiazoline-4-carboxylic acid, 4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid, Firefly Luciferin
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1 MG
74,30 €
5 MG
229,00 €
10 MG
412,00 €
50 MG
1 510,00 €
100 MG
2 440,00 €
74,30 €
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A propos de cet article
Formule empirique (notation de Hill) :
C11H8N2O3S2
Numéro CAS:
Poids moléculaire :
280.32
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
219-981-3
MDL number:
Beilstein/REAXYS Number:
30484
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D-Luciferin, synthetic
InChI key
BJGNCJDXODQBOB-SSDOTTSWSA-N
InChI
1S/C11H8N2O3S2/c14-5-1-2-6-8(3-5)18-10(12-6)9-13-7(4-17-9)11(15)16/h1-3,7,14H,4H2,(H,15,16)/t7-/m1/s1
SMILES string
OC(=O)[C@H]1CSC(=N1)c2nc3ccc(O)cc3s2
biological source
synthetic
assay
≥98% (HPLC)
form
powder
solubility
DMSO: 10 mg/mL, clear, colorless to faintly yellow
fluorescence
λex 328 nm; λem 532 nm in H2O
storage temp.
−20°C
Quality Level
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1 of 4
Cet article | L6882 | L6152 | 50227 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥99% (HPLC) | assay ≥98.0% (HPLC) |
| solubility DMSO: 10 mg/mL, clear, colorless to faintly yellow | solubility H2O: soluble | solubility DMSO: 10 mg/mL, clear, colorless to faintly yellow | solubility water: soluble |
| Quality Level 300 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| form powder | form lyophilized powder | form powder | form powder or crystals |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| fluorescence λex 328 nm; λem 532 nm in H2O | fluorescence λex 328 nm; λem 532 nm in H2O | fluorescence - | fluorescence - |
Application
D-Luciferin has been used in determining luciferase activity by luciferase assay in mice[1] and Arabidopsis thaliana seeds.[2] It has also been used in measuring bioluminescence in neonatal rat ventricular cardiomyocytes.[3]
Substrate for firefly luciferase with a Km of approx 2 μM.
Biochem/physiol Actions
D-Luciferin uptake within the cells is regulated by the adenosine triphosphate (ATP)-binding cassette (ABC) transporter inhibitors like ATP-binding cassette transporter G2 (ABCG2)/ breast cancer resistance protein (BCRP) inhibitor fumitremorgin C. This substrate is oxidized by firefly luciferase that results in emitting a photon, which has the capability of passing through living tissues.[4]
General description
D-Luciferin is a small molecule present abundantly in bioluminescent organisms. This molecule is sensitive to oxygen and light.[5]
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Réf. du produit
Description
Tarif
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Imaging and Spectroscopic Analysis of Living Cells
Test (2012)
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Firefly luciferase is a sensitive reporter for gene studies due to its absence in mammalian cells or tissues.
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Is this product suitable for injection into mice for in vivo applications after being dissolved in DMSO?
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