O9504

Oxaloacetic acid

Name: Oxaloacetic acid
Brand: SIGMA
Price: 1080 BRL

powder, suitable for hybridoma

Synonym(s):

2-Oxosuccinic acid, Ketosuccinic acid, Oxalacetic acid, Oxobutanedioic acid

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5 G

R$1,080.00

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About This Item

Linear Formula:

HOOCCH₂COCOOH

CAS Number:

328-42-7

Molecular Weight:

132.07

UNSPSC Code:

12352205

NACRES:

NA.75

PubChem Substance ID:

24898071

EC Number:

206-329-8

Beilstein/REAXYS Number:

1705475

MDL number:

MFCD00002592

Key Documents

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Product Name

Oxaloacetic acid, powder, suitable for hybridoma

InChI key

KHPXUQMNIQBQEV-UHFFFAOYSA-N

InChI

1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)

SMILES string

OC(=O)CC(=O)C(O)=O

assay

≥97% (HPLC)

form

powder

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

solubility

H₂O: 100 mg/mL

storage temp.

−20°C

Quality Level

200

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This Item	O7753	O4126	P3662
Sigma-Aldrich O9504 Oxaloacetic acid	Sigma-Aldrich O7753 Oxaloacetic acid	Sigma-Aldrich O4126 Oxaloacetic acid	Sigma-Aldrich P3662 Sodium pyruvate
assay ≥97% (HPLC)	assay ≥97% (HPLC)	assay ≥97% (HPLC)	assay ≥99%
technique(s) cell culture \| hybridoma: suitable	technique(s) cell culture \| insect: suitable, cell culture \| mammalian: suitable	technique(s) -	technique(s) cell culture \| hybridoma: suitable
solubility H₂O: 100 mg/mL	solubility H₂O: 100 mg/mL	solubility H₂O: 100 mg/mL, clear to slightly hazy, colorless to light yellow	solubility H₂O: 100 mg/mL
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C

Application

Use as a TCA (Krebs cycle) intermediate supplement in hybridoma cell culture applications. Enhances hybridoma growth and productivity.

related product

Product No.

Description

Pricing

O7753

Oxaloacetic acid, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97% (HPLC)

pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number

0000501417

0000366662

0000308464

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Novel insights into the biotin carboxylase domain reactions of pyruvate carboxylase from Rhizobium etli.

Tonya N Zeczycki et al.

Biochemistry, 50(45), 9724-9737 (2011-10-01)

The catalytic mechanism of the MgATP-dependent carboxylation of biotin in the biotin carboxylase domain of pyruvate carboxylase from R. etli (RePC) is common to the biotin-dependent carboxylases. The current site-directed mutagenesis study has clarified the catalytic functions of several residues

The effects of oxaloacetate on hydrogen peroxide generation from ascorbate and epigallocatechin gallate in cell culture media: potential for altering cell metabolism.

Lee Hua Long et al.

Biochemical and biophysical research communications, 417(1), 446-450 (2011-12-15)

Several phenolic compounds as well as ascorbate can oxidise in certain cell culture media (especially Dulbecco's modified Eagle's medium (DMEM)) to generate hydrogen peroxide. Addition of oxaloacetate decreased the levels of H(2)O(2) detected and the oxaloacetate was depleted. Oxaloacetate was

Biochemical and histologic pathology in an infant with cross-reacting material (negative) pyruvate carboxylase deficiency.

L T Wong et al.

Pediatric research, 20(3), 274-279 (1986-03-01)

An infant with the acute neonatal form of pyruvate carboxylase deficiency (cross-reacting material negative) presented with severe intractable lactic acidosis within 4 h after birth. He also had hyperammonemia, hypercitrullinemia, and hyperlysinemia. Plasma glutamine was not elevated. He had a

Effect of glutamate and blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome and pathohistology of the hippocampus after traumatic brain injury in rats.

Alexander Zlotnik et al.

Anesthesiology, 116(1), 73-83 (2011-12-02)

Decreasing blood glutamate concentrations after traumatic brain injury accelerates brain-to-blood glutamate efflux, leading to improved neurologic outcomes. The authors hypothesize that treatment with blood glutamate scavengers should reduce neuronal cell loss, whereas administration of glutamate should worsen outcomes. The authors

Oxaloacetate: a novel neuroprotective for acute ischemic stroke.

Francisco Campos et al.

The international journal of biochemistry & cell biology, 44(2), 262-265 (2011-11-17)

It is well established that glutamate acts as an important mediator of neuronal degeneration during cerebral ischemia. Different kind of glutamate antagonists have been used to reduce the deleterious effects of glutamate. However, their preclinical success failed to translate into

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