WH0057804M1

Monoclonal Anti-POLD4 antibody produced in mouse

Name: Monoclonal Anti-POLD4 antibody produced in mouse
Brand: SIGMA
Price: 3131 BRL

clone 2B11, ascites fluid

Synonym(s):

Anti-POLDS, Anti-p12, Anti-polymerase (DNA-directed), delta 4

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200 μL

R$3,131.00

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

Key Documents

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

2B11, monoclonal

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: 1:500-1:1000

isotype

IgG2bκ

GenBank accession no.

BC001334

UniProt accession no.

Q9HCU8

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... POLD4(57804)

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Show Differences

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This Item	SAB1405227	SAB4200054	SAB1405011
Sigma-Aldrich WH0057804M1 Monoclonal Anti-POLD4 antibody produced in mouse	Sigma-Aldrich SAB1405227 Monoclonal Anti-POLD4 antibody produced in mouse	Sigma-Aldrich SAB4200054 Anti-DNA polymerase δ p50 antibody, Rat monoclonal	Sigma-Aldrich SAB1405011 Monoclonal Anti-PLDN antibody produced in mouse
species reactivity human	species reactivity human	species reactivity human	species reactivity human
clone 2B11, monoclonal	clone 2C11, monoclonal	clone PDK 7B4, monoclonal	clone 3D2, monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Gene Information human ... POLD4(57804)	Gene Information human ... POLD4(57804)	Gene Information human ... POLD2(5425)	Gene Information human ... PLDN(26258)
antibody form ascites fluid	antibody form purified immunoglobulin	antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin
biological source mouse	biological source mouse	biological source rat	biological source mouse

General description

DNA polymerase δ 4 (POLD4), also known as p12, is the smallest subunit of DNA polymerase (Pol) δ. It is encoded by the gene mapped to human chromosome 11q13.2.

The DNA polymerase delta complex is involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen (PCNA; MIM 176740), the multisubunit replication factor C (see MIM 102579), and the 4 subunit polymerase complex: POLD1 (MIM 174761), POLD2 (MIM 600815), POLD3 (MIM 611415), and POLD4 (Liu and Warbrick, 2006 [PubMed 16934752]).

Immunogen

POLD4 (AAH01334, 1 a.a. ~ 34 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MGRKRLITDSYPVVKRREGPAGHSKGELAPELGL

Biochem/physiol Actions

DNA polymerase (Pol) δ plays a vital role in DNA replication, DNA repair processes and genetic recombination. POLD4 stabilizes the Pol δ holoenzyme. In addition, it also facilitates pol δ-PCNA complex stabilization. Proteolysis of POLD4 in response to DNA damage leads to the consequent conversion of the holoenzyme pol δ4 to the heterotrimer pol δ3. Pol δ3 acts as an antimutator polymerase and is supposed to enhance surveillance against mutagenesis. Downregulated expression of the gene is associated with the genomic instability in lung cancer.

Physical form

Solution

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

H3131-2B11

08046-2B11

07345-2B11

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A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta.

Zhang S, et al.

The Journal of Biological Chemistry, 15330-40 null

Regulation of DNA Polymerase POLD4 Influences Genomic Instability in Lung Cancer

Huang QM, et al.

Cancer Research, 8407-16 null

PPP6R3?USP6 amplification: Novel oncogenic mechanism in malignant nodular fasciitis

Guo R, et al.

Genes Chromosomes Cancer, 640-9 null

Proteolysis of the Human DNA Polymerase Delta Smallest Subunit p12 by μ-Calpain in Calcium-Triggered Apoptotic HeLa Cells

Fan X, et al.

PLoS ONE null

Human DNA polymerase delta is a pentameric holoenzyme with a dimeric p12 subunit.

Prashant Khandagale et al.

Life science alliance, 2(2) (2019-03-20)

Human DNA polymerase delta (Polδ), a holoenzyme consisting of p125, p50, p68, and p12 subunits, plays an essential role in DNA replication, repair, and recombination. Herein, using multiple physicochemical and cellular approaches, we found that the p12 protein forms a

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