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900921

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average Mn 2,000, PLGA Mn 3,000, lactide:glycolide 50:50

Synonym(s):

PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA

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About This Item

Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
NACRES:
NA.23
UNSPSC Code:
51171641

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Product Name

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide), PEG average Mn 2,000, PLGA Mn 3,000, lactide:glycolide 50:50

form

crystals

feed ratio

lactide:glycolide 50:50

mol wt

PEG average Mn 2,000
PLGA Mn 3,000

impurities

≤5000 ppm (residual monomer by GC)

shipped in

dry ice

storage temp.

−20°C

Quality Level

100

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This Item
913138911429911399
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) PEG average Mn 2,000, PLGA Mn 3,000, lactide:glycolide 50:50

Sigma-Aldrich

900921

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) PEG average Mn 2,000, PLGA average Mn 10,000, lactide:glycolide 50:50

Sigma-Aldrich

913138

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) PEG average Mn 5,000, PLGA average Mn 5,000, lactide:glycolide 80:20

Sigma-Aldrich

911429

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) PEG average Mn 2,000, PLGA average Mn 10,000, lactide:glycolide 80:20

Sigma-Aldrich

911399

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

form

crystals

form

powder or solid

form

powder

form

powder or chunks

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

mol wt

PEG average Mn 2,000, PLGA Mn 3,000

mol wt

PEG average Mn 2,000, PLGA average Mn 10,000 (by NMR)

mol wt

PEG average Mn 5,000 (by NMR), PLGA average Mn 5,000 (by NMR)

mol wt

PEG average Mn 2,000 (by NMR), PLGA average Mn 10,000 (by NMR)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

impurities

≤5000 ppm (residual monomer by GC)

impurities

-

impurities

≤500 ppm (GC)

impurities

-

shipped in

dry ice

shipped in

-

shipped in

-

shipped in

-

Application

Biocompatible block copolymer can be used in the formation of nanoparticles for drug delivery. Potential use in the targeted and/or controlled release of cancer drugs, anti-inflammatory drugs, antibiotics, or anesthetic agents.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ8183

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Miles A Miller et al.
Nature communications, 6, 8692-8692 (2015-10-28)
Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their
Fabienne Danhier et al.
Journal of controlled release : official journal of the Controlled Release Society, 133(1), 11-17 (2008-10-28)
The purpose of this study was to develop Cremophor EL-free nanoparticles loaded with Paclitaxel (PTX), intended to be intravenously administered, able to improve the therapeutic index of the drug and devoid of the adverse effects of Cremophor EL. PTX-loaded PEGylated
Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these

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