05-796

Anti-Akt1/PKBα Antibody, clone AW24, rabbit monoclonal

Name: Anti-Akt1/PKBα Antibody, clone AW24, rabbit monoclonal
Brand: MM
Price: 623 CAD

clone AW24, Upstate^®, from rabbit

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100 μL

$623.00

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

AW24, monoclonal

species reactivity

human, mouse, rat

manufacturer/tradename

Upstate^®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_005163

UniProt accession no.

P31749

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... AKT1(207)

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This Item	05-736	05-536	SAB5600066
Sigma-Aldrich 05-796 Anti-Akt1/PKBα Antibody, clone AW24, rabbit monoclonal	Sigma-Aldrich 05-736 Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone SK703, rabbit monoclonal	Sigma-Aldrich 05-536 Anti-IKKα Antibody, clone 14A231	Sigma-Aldrich SAB5600066 Anti-AKT1 antibody, Rabbit monoclonal
species reactivity human, mouse, rat	species reactivity human, mouse	species reactivity human, monkey, mouse	species reactivity human
antibody form purified antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
clone AW24, monoclonal	clone SK703, monoclonal	clone 14A231, monoclonal	clone RM252, monoclonal, recombinant monoclonal
biological source rabbit	biological source rabbit	biological source mouse	biological source -
Gene Information human ... AKT1(207)	Gene Information human ... AKT1(207)	Gene Information human ... CHUK(1147)	Gene Information human ... AKT1(207)
shipped in dry ice	shipped in wet ice	shipped in dry ice	shipped in wet ice

General description

~60kDa

Immunogen

Peptide (C-RPHFPQFSYSASGTA) corresponding to the C-terminal (residues 466-480) of rat Akt1/PKBα

Application

Detect Akt1/PKBα using this Anti-Akt1 Antibody, clone AW24 validated for use in IP & WB.

Research Category
Signaling

Research Sub Category
PI3K, Akt, & mTOR Signaling

Biochem/physiol Actions

Akt1/PKBα

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%

Format: Purified

Protein A purified

Preparation Note

2 years at -20°C

Analysis Note

routinely evaluated by immunoblot on RIPA lysates from human HEK293 cells

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pricing

ZRB2028

Anti-AKT1 Antibody, clone 4K6 ZooMAb^® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

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Translocation of nuclear chromatin distribution to the periphery reflects dephosphorylated threonine-821/826 of the retinoblastoma protein (pRb) in T24 cells treated with Bacillus Calmette-Guérin.

Toshitaka Uehara et al.

Cytotechnology, 75(1), 49-62 (2023-01-31)

The standard treatment for non-muscle-invasive bladder cancer is intravesical Bacillus Calmette-Guérin (BCG) therapy, which is considered the only intravesical therapy that reduces the risk of progression to muscle-invasive cancer. BCG unresponsiveness, in which intravesical BCG therapy is ineffective, has become

Modulation of serotonin transporter function by kappa-opioid receptor ligands.

Santhanalakshmi Sundaramurthy et al.

Neuropharmacology, 113(Pt A), 281-292 (2016-11-05)

Kappa opioid receptor (KOR) agonists produce dysphoria and psychotomimesis. While KOR agonists produce pro-depressant-like effects, KOR antagonists produce anti-depressant-like effects in rodent models. The cellular mechanisms and downstream effector(s) by which KOR ligands produce these effects are not clear. KOR

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Choi, JC; Muchir, A; Wu, W; Iwata, S; Homma, S; Morrow, JP; Worman, HJ

Science Translational Medicine null

Nuclear co-expression of p21 and p27 induced effective cell-cycle arrest in T24 cells treated with BCG.

Sumiko Watanabe et al.

Cytotechnology, 71(1), 219-229 (2019-01-04)

A proposed mechanism underlying the effect of bacillus Calmette-Guérin (BCG) treatment for bladder cancer cells is as follows: BCG-induced crosslinking of cell-surface receptors results in the activation of signaling cascades, including cell-cycle regulators. However, the clinical significance of cell-cycle regulators

Identification and quantification of AKT isoforms and phosphoforms in breast cancer using a novel nanofluidic immunoassay.

Demetris C Iacovides et al.

Molecular & cellular proteomics : MCP, 12(11), 3210-3220 (2013-08-10)

Breast cancer subtype-specific molecular variations can dramatically affect patient responses to existing therapies. It is thought that differentially phosphorylated protein isoforms might be a useful prognostic biomarker of drug response in the clinic. However, the accurate detection and quantitative analysis

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