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Y0001197

Cetirizine for peak identification

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Cetirizine dihydrochloride, [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C21H25ClN2O3 · 2HCl
CAS Number:
83881-52-1
Molecular Weight:
461.81
NACRES:
NA.24
PubChem Substance ID:
329831302
UNSPSC Code:
41116107
MDL number:
MFCD00941428

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Product Name

Cetirizine for peak identification, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H

SMILES string

OC(COCCN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1)=O.[H]Cl.[H]Cl

InChI key

PGLIUCLTXOYQMV-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

cetirizine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... HRH1(3269)

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1 of 4

This Item
BP8371102929BP1081
Cetirizine for peak identification European Pharmacopoeia (EP) Reference Standard

Y0001197

Cetirizine for peak identification

Cetirizine hydrochloride British Pharmacopoeia (BP) Reference Standard

BP837

Cetirizine hydrochloride

Cetirizine dihydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1102929

Cetirizine dihydrochloride

Cetirizine impurity standard British Pharmacopoeia (BP) Reference Standard

BP1081

Cetirizine impurity standard

manufacturer/tradename

EDQM

manufacturer/tradename

BP

manufacturer/tradename

USP

manufacturer/tradename

BP

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

format

neat

format

neat

format

mixture

API family

cetirizine

API family

cetirizine

API family

cetirizine

API family

cetirizine

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

Application

Cetirizine for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Cetirizine hydrochloride is a non-sedating type histamine H1-receptor antagonist.
Cetirizine hydrochloride is an orally active and selective H1-receptor antagonist. Antihistaminic; Piperazines. Non-sedating type histamine H1-receptor antagonist; major metabolite of hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

comparable product

Product No.
Description
Pricing

related product

Product No.
Description
Pricing

C0980651

Cetirizine impurity A, European Pharmacopoeia (EP) Reference Standard

1102930

Cetirizine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1112467

4-Chlorobenzophenone, United States Pharmacopeia (USP) Reference Standard

1102952

Cetirizine Related Compound C, United States Pharmacopeia (USP) Reference Standard

1102941

Cetirizine Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1710

Cetirizine hydrochloride Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

1102963

Cetirizine Related Compound G, United States Pharmacopeia (USP) Reference Standard

BP441

1,4-Bis(4-chlorobenzhydryl)piperazine, British Pharmacopoeia (BP) Reference Standard

PHR2620

4-Chlorobenzophenone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2852

Cetirizine Related Compound G, certified reference material, pharmaceutical secondary standard

PHR3195

Levocetirizine Dihydrochloride, pharmaceutical secondary standard, certified reference material

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Ko-Haung Lue et al.
International journal of pediatric otorhinolaryngology, 76(7), 994-1001 (2012-04-20)
Supplementary consumption of probiotics may temporarily alter the intestinal microflora of infants and children, thereby preventing and treating allergic disorders. To compare the clinical efficacy of levocetirizine with that of levocetirizine plus Lactobacillus johnsonii EM1 (Lj EM1) for treating perennial
Macheng Yan et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 33(1), 60-64 (2013-04-20)
To investigate the potential rules and knowledge of Traditional Chinese Medicine (TCM) and Western Medicine (WM) treatment on chronic urticaria (CU) based on data-mining methods. Sixty patients with chronic urticaria, treated with TCM and WM, were selected. Gray correlation analyses
Susan D Mathias et al.
Allergy and asthma proceedings, 33(2), 186-190 (2012-04-25)
The Urticaria Patient Daily Diary, including the Urticaria Activity Score, has recently been validated in adults with chronic idiopathic urticaria (CIU), but its validity in adolescents is unknown. This study was designed to (1) assess the content validity of the
Arnold Bahlmann et al.
Chemosphere, 89(11), 1278-1286 (2012-06-12)
Carbamazepine (CBZ), caffeine and cetirizine were monitored by enzyme-linked immunosorbent assays (ELISAs) in surface and wastewaters from Berlin, Germany. This fast and cost-efficient method enabled to assess the spatial and temporal variation of these anthropogenic markers in a high-throughput screening.
Agnieszka Biedroł et al.
Pediatrics, 133(4), e1068-e1071 (2014-03-26)
The occurrence of stabbing headaches in children requires a thorough diagnostic approach that excludes secondary headaches. The organic background should be taken into consideration when alarming symptoms occur, such as a purely 1-sided location, a change in the character of
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