A1663

Atrial Natriuretic Peptide human

≥97% (HPLC)

• Synonym(s): ANF 1-28, hANF
• Empirical Formula (Hill Notation): C₁₂₇H₂₀₃N₄₅O₃₉S₃
• CAS Number: 91917-63-4
• Molecular Weight: 3080.44
• NACRES: NA.32
• PubChem Substance ID: 24890580
• UNSPSC Code: 12352200
• MDL number: MFCD00076226

Properties

• Product Name: Atrial Natriuretic Peptide human, ≥97% (HPLC)
• InChI: 1S/C127H205N45O39S3/c1-9-64(6)99(121(209)150-52-94(182)151-65(7)100(188)155-76(34-35-91(129)179)109(197)167-85(56-174)104(192)149-53-96(184)153-78(43-62(2)3)102(190)148-54-97(185)154-89(60-212)119(207)164-82(48-92(130)180)114(202)169-86(57-175)116(204)163-81(46-67-23-14-11-15-24-67)113(201)158-73(27-18-39-143-125(135)136)107(195)166-84(122(210)211)47-68-30-32-69(178)33-31-68)172-111(199)75(29-20-41-145-127(139)140)159-115(203)83(49-98(186)187)165-110(198)77(36-42-214-8)160-105(193)71(25-16-37-141-123(131)132)152-95(183)51-146-93(181)50-147-103(191)80(45-66-21-12-10-13-22-66)162-120(208)90(61-213)171-118(206)88(59-177)170-117(205)87(58-176)168-108(196)74(28-19-40-144-126(137)138)156-106(194)72(26-17-38-142-124(133)134)157-112(200)79(44-63(4)5)161-101(189)70(128)55-173/h10-15,21-24,30-33,62-65,70-90,99,173-178,212-213H,9,16-20,25-29,34-61,128H2,1-8H3,(H2,129,179)(H2,130,180)(H,146,181)(H,147,191)(H,148,190)(H,149,192)(H,150,209)(H,151,182)(H,152,183)(H,153,184)(H,154,185)(H,155,188)(H,156,194)(H,157,200)(H,158,201)(H,159,203)(H,160,193)(H,161,189)(H,162,208)(H,163,204)(H,164,207)(H,165,198)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,186,187)(H,210,211)(H4,131,132,141)(H4,133,134,142)(H4,135,136,143)(H4,137,138,144)(H4,139,140,145)
• SMILES string: CCC(C)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(O)=O)NC(=O)C(CCSC)NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(N)CO)C(=O)NCC(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC(CO)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CS)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NC(Cc2ccccc2)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc3ccc(O)cc3)C(O)=O
• InChI key: KGZJRXKGJRJKCB-UHFFFAOYSA-N
• assay: ≥97% (HPLC)
• form: powder
• UniProt accession no.: P01160
• storage temp.: −20°C
• Quality Level: 200
• Gene Information: human ... NPPA(4878)

Description

Application

Atrial natriuretic peptide (ANP) has been used to study its cross reactivity in melanin concentrating hormone (MCH) assay.[1] It has also been used to study its effects in nerve fibres and nerve cell bodies.[2]

Biochem/physiol Actions

Atrial natriuretic peptide (ANP) is a cardiac hormone, which maintains electrolyte homeostasis. It prevents adrenocorticotropic hormone (ACTH) release and arginine vasopressin secretion. ANP functions as a neurotransmitter and modulates pituitary and vegetative functions.[3]

Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.

Exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors.

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)