14-680
HIPK3 Protein, active, 10 µg
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A propos de cet article
Code UNSPSC :
12352202
eCl@ss :
32160405
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Laissez-nous vous aiderProduit recombinant
expressed in baculovirus infected Sf21 cells
Niveau de qualité
Description
protein target HIPK3
Produit purifié par
(Ni2+/NTA-agarose)
Technique(s)
activity assay: suitable
Numéro d'accès UniProt
Informations sur le gène
human ... HIPK3(10114)
Description générale
49.7kDa
FUNCTION: SwissProt: Q9H422 # Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors.
SIZE: 1215 amino acids; 133743 Da
SUBUNIT: Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity). Interacts with UBL1/SUMO-1.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.
PTM: Autophosphorylated, but autophosphorylation is not required for catalytic activity (By similarity). & May be sumoylated (By similarity).
SIMILARITY: SwissProt: Q9H422 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. & Contains 1 protein kinase domain.
SIZE: 1215 amino acids; 133743 Da
SUBUNIT: Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity). Interacts with UBL1/SUMO-1.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.
PTM: Autophosphorylated, but autophosphorylation is not required for catalytic activity (By similarity). & May be sumoylated (By similarity).
SIMILARITY: SwissProt: Q9H422 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. & Contains 1 protein kinase domain.
Notes préparatoires
Stable 6 months at -70°C from date of shipment
Remarque sur l'analyse
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
routinely evaluated by phosphorylation of MBP (Catalog # 13-104)
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Skin Sens. 1
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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