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Merck

324879

CCT020312

≥98% (HPLC), solid, EIF2AK3 activator, Calbiochem®

Synonyme(s) :

EIF2AK3 Activator, CCT020312, 6-Bromo-3-[5-(4-bromo-phenyl)-1-(3-diethylamino-propionyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-phenyl-1H-quinolin-2-one, PERK activator, CCT020312

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5 MG

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A propos de cet article

Formule empirique (notation de Hill) :
C31H30Br2N4O2
Numéro CAS:
324759-76-4
Poids moléculaire :
650.40
Numéro MDL:
MFCD01004667
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Principaux documents

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Nom du produit

EIF2AK3 Activator, CCT020312, The EIF2AK3 Activator, CCT020312 modulates the biological activity of EIF2AK3.

Niveau de qualité

100

Essai

≥98% (HPLC)

Forme

solid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
protect from light

Couleur

yellow-white

Solubilité

DMSO: 50 mg/mL

Conditions d'expédition

ambient

Température de stockage

−20°C

Chaîne SMILES 

O=C1C(C2=NN(C(CCN(CC)CC)=O)C(C3=CC=C(Br)C=C3)C2)=C(C4=CC=CC=C4)C5=CC(Br)=CC=C5N1

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1 of 4

Cet article
124018382120124030
EIF2AK3 Activator, CCT020312 The EIF2AK3 Activator, CCT020312 modulates the biological activity of EIF2AK3.

Sigma-Aldrich

324879

EIF2AK3 Activator, CCT020312

Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a cell-permeable, reversible inhibitor of Akt1/Akt2 (IC50 = 58 nM, 210 nM, & 2.12 µM for Akt1, Akt2, and Akt3, respectively).

Sigma-Aldrich

124018

Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2

Histone Acetyltransferase Activator, CTB The Histone Acetyltransferase Activator, CTB, also referenced under CAS 451491-47-7, modulates the biological activity of Histone. This small molecule/inhibitor is primarily used for Cell Structure applications.

Sigma-Aldrich

382120

Histone Acetyltransferase Activator, CTB

Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 The Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

124030

Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2

form

solid

form

solid

form

solid

form

solid

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥97% (mixture of regioisomers, HPLC)

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

Description générale

A dihydropyrazol derivative that acts as a selective activator of eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3/PERK) and increases the phosphorylation of EIF2A at Ser51 in HT29 and MCF7 cells. Does not inhibit the activity of cyclin dependent kinases, but causes a rapid loss of cyclin D expression. Also shown to block Rb protein phosphorylation (EC50 = 4.2 µM) in HT29 cells. Reported to sensitize cancer cells with defective taxane-induced EIF2A phosphorylation to paclitaxel treatment. Induces a long-term inhibition of cell proliferation even after its removal (GI50 = 3.1 µM).

Conditionnement

Packaged under inert gas

Notes préparatoires

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Stockwell, S. R., et al. 2011. Plos One In press.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Toxicity: Standard Handling (A)

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Shin-Ichi Ikeda et al.
Nature communications, 13(1), 5859-5859 (2022-10-11)
Axial length is the primary determinant of eye size, and it is elongated in myopia. However, the underlying mechanism of the onset and progression of axial elongation remain unclear. Here, we show that endoplasmic reticulum (ER) stress in sclera is
Simon R Stockwell et al.
PloS one, 7(1), e28568-e28568 (2012-01-19)
Human cancers often contain genetic alterations that disable G1/S checkpoint control and loss of this checkpoint is thought to critically contribute to cancer generation by permitting inappropriate proliferation and distorting fate-driven cell cycle exit. The identification of cell permeable small
Himanshu Soni et al.
Oncogenesis, 9(2), 18-18 (2020-02-15)
PKR-like kinase (PERK) plays a significant role in inducing angiogenesis in various cancer types including glioblastoma. By proteomics analysis of the conditioned medium from a glioblastoma cell line treated with a PERK inhibitor, we showed that peptidylglycine α-amidating monooxygenase (PAM)
Kai Chen et al.
Aging cell, 21(4), e13592-e13592 (2022-03-18)
Delirium is the most common postoperative complication in older patients after prolonged anesthesia and surgery and is associated with accelerated cognitive decline and dementia. The neuronal pathogenesis of postoperative delirium is largely unknown. The unfolded protein response (UPR) is an

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