567021

Simvastatin Sodium Salt

HMG-CoA reductase inhibitor, (Beige solid)

• Synonyme(s) : L-Type Calcium Channel Blocker VI, Simvastatin, Sodium Salt - Calbiochem
• Formule linéaire : C25H39O6.Na
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.32

Propriétés

• Nom du produit: Simvastatin, Sodium Salt - Calbiochem,
• Forme: (Beige solid)
• Niveau de qualité: 100
• Conditions de stockage: OK to freeze
• Solubilité: soluble (DMSO (100 mg/ml), Ethanol (25 mg/ml), or H2O (5 mg/ml))
• Température de stockage: −20°C

Description

Description générale

Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an active form; no treatment with NaOH in ethanol is required for its activation.