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Merck

AB3852

Anti-Cortactin Antibody, phospho-specific (Tyr421)

Chemicon®, from rabbit

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A propos de cet article

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

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Source biologique

rabbit

Niveau de qualité

Forme d'anticorps

affinity purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

human, rat

Fabricant/nom de marque

Chemicon®

Technique(s)

western blot: suitable

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

phosphorylation (pTyr421)

Informations sur le gène

human ... CTTN(2017)

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Cet article
SAB4504372HPA057242MABT524
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified antibody

Gene Information

human ... CTTN(2017)

Gene Information

human ... CTTN(2017)

Gene Information

human ... CTTN(2017)

Gene Information

human ... CTTN(2017)

species reactivity

human, rat

species reactivity

human, mouse, rat

species reactivity

human

species reactivity

mouse

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

ambient

Immunogène

Epitope: phospho-specific (Tyr421)
Rabbit anti-Cortactin (Y421) polyclonal antibody was raised against a peptide corresponding to residues surrounding phosphorylated Y421of human cortactin.

Application

Anti-Cortactin Antibody, phospho-specific (Tyr421) detects level of Cortactin & has been published & validated for use in WB.
Research Category
Cell Structure
Research Sub Category
Cytoskeleton
Western blot: 1-2 μg/mL

Optimal working dilutions must be determined by end user.

Actions biochimiques/physiologiques

Recognizes Cortactin phosphorylated on tyrosine 421. Cortactin is an 80-85 kDa actin-binding protein, which consists of a variety of protein domains. The nature and function of these domains, coupled with the presence of multiple consensus sites for phosphorylation by tyrosine and serine/threonine kinases, suggests that cortactin integrates activation of specific signaling pathways with cytoskeletal reorganization.

Forme physique

Affinity purified immunoglobulin. Liquid in 1mg/mL in PBS with 0.1% Sodium azide.

Notes préparatoires

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months after receipt.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Hippocampal Cortactin Levels are Reduced Following Spatial Working Memory Formation, an Effect Blocked by Chronic Calpain Inhibition.
Olson, ML; Ingebretson, AE; Harmelink, KM
Brain sciences null
Jakob Knorr et al.
European journal of microbiology & immunology, 10(1), 20-27 (2020-05-05)
The gastric pathogen Helicobacter pylori colonizes approximately half of the human world population. The bacterium injects the effector protein cytotoxin associated gene A (CagA) via a type-IV secretion system into host epithelial cells, where the protein becomes phosphorylated at specific
Nayden G Naydenov et al.
Cells, 11(9) (2022-05-15)
Recurrent chronic mucosal inflammation, a characteristic of inflammatory bowel diseases (IBD), perturbs the intestinal epithelial homeostasis resulting in formation of mucosal wounds and, in most severe cases, leads to colitis-associated colon cancer (CAC). The altered structure of epithelial cell-cell adhesions
Yu Yu et al.
Oncogene, 37(28), 3778-3789 (2018-04-13)
Cell motility and invasiveness are prerequisites for dissemination, and largely account for cancer mortality. We have identified an actionable kinase, spleen tyrosine kinase (SYK), which is keenly tightly associated with tumor progression in ovarian cancer. Here, we report that active
Lizandra Jimenez et al.
Archives of pathology & laboratory medicine, 139(11), 1349-1361 (2015-07-15)
Head and neck squamous cell carcinoma (HNSCC) is a highly invasive cancer with an association with locoregional recurrence and lymph node metastasis. We have previously reported that low microRNA-375 (miR-375) expression levels correlate with poor patient survival, increased locoregional recurrence

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