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Merck

Y0001197

Cetirizine dihydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :
C21H25ClN2O3 · 2HCl
Numéro CAS:
83881-52-1
Poids moléculaire :
461.81
Numéro MDL:
MFCD00941428
Code UNSPSC :
41116107
ID de substance PubChem :
329831302
Nomenclature NACRES :
NA.24

Principaux documents

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Qualité

pharmaceutical primary standard

Famille d'API

cetirizine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

OC(COCCN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1)=O.[H]Cl.[H]Cl

InChI

1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H

Clé InChI

PGLIUCLTXOYQMV-UHFFFAOYSA-N

Informations sur le gène

human ... HRH1(3269)

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Cet article
BP8371102929BP1081
Cetirizine dihydrochloride European Pharmacopoeia (EP) Reference Standard

Y0001197

Cetirizine dihydrochloride

Cetirizine dihydrochloride British Pharmacopoeia (BP) Reference Standard

BP837

Cetirizine dihydrochloride

Cetirizine dihydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1102929

Cetirizine dihydrochloride

Cetirizine dihydrochloride British Pharmacopoeia (BP) Reference Standard

BP1081

Cetirizine dihydrochloride

manufacturer/tradename

EDQM

manufacturer/tradename

BP

manufacturer/tradename

USP

manufacturer/tradename

BP

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

format

neat

format

neat

format

mixture

API family

cetirizine

API family

cetirizine

API family

cetirizine

API family

cetirizine

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cetirizine for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Cetirizine hydrochloride is a non-sedating type histamine H1-receptor antagonist.
Cetirizine hydrochloride is an orally active and selective H1-receptor antagonist. Antihistaminic; Piperazines. Non-sedating type histamine H1-receptor antagonist; major metabolite of hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit comparable

Réf. du produit
Description
Tarif

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

C0980651

Cetirizine impurity A, European Pharmacopoeia (EP) Reference Standard

1102930

Cetirizine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1112467

4-Chlorobenzophenone, United States Pharmacopeia (USP) Reference Standard

1102952

Cetirizine Related Compound C, United States Pharmacopeia (USP) Reference Standard

1102941

Cetirizine Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1710

Cetirizine hydrochloride Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

1102963

Cetirizine Related Compound G, United States Pharmacopeia (USP) Reference Standard

BP441

1,4-Bis(4-chlorobenzhydryl)piperazine, British Pharmacopoeia (BP) Reference Standard

PHR2620

4-Chlorobenzophenone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2852

Cetirizine Related Compound G, certified reference material, pharmaceutical secondary standard

PHR3195

Levocetirizine Dihydrochloride, pharmaceutical secondary standard, certified reference material

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Conseils de prudence

P301 + P312 + P330

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Céline Caillet et al.
British journal of clinical pharmacology, 74(5), 886-889 (2012-03-13)
The physicochemical properties of racemates and stereoisomers of medicines can differ significantly, and this may affect the side-effect profile in addition to the pharmacokinetics and intended pharmacology. This is a study to investigate the profile of adverse drug reactions of
Arnold Bahlmann et al.
Chemosphere, 89(11), 1278-1286 (2012-06-12)
Carbamazepine (CBZ), caffeine and cetirizine were monitored by enzyme-linked immunosorbent assays (ELISAs) in surface and wastewaters from Berlin, Germany. This fast and cost-efficient method enabled to assess the spatial and temporal variation of these anthropogenic markers in a high-throughput screening.
Benno Brinkhaus et al.
Annals of internal medicine, 158(4), 225-234 (2013-02-20)
Chinese translation Acupuncture is frequently used to treat seasonal allergic rhinitis (SAR) despite limited scientific evidence. To evaluate the effects of acupuncture in patients with SAR. Randomized, controlled multicenter trial. (ClinicalTrials.gov: NCT00610584) 46 specialized physicians in 6 hospital clinics and
Joya S Griffin et al.
The Canadian veterinary journal = La revue veterinaire canadienne, 53(1), 47-50 (2012-07-04)
Cetirizine hydrochloride was administered orally at 5 mg/cat, q24h, to 32 cats with allergic skin disease. Pruritus was reduced in 41% (13/32) of the cats. The antipruritic effect was repeatable and sustainable. There was no significant association between patient age
Agnieszka Biedroł et al.
Pediatrics, 133(4), e1068-e1071 (2014-03-26)
The occurrence of stabbing headaches in children requires a thorough diagnostic approach that excludes secondary headaches. The organic background should be taken into consideration when alarming symptoms occur, such as a purely 1-sided location, a change in the character of
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