A211040

DMT-2′O-TBDMS-rA(bz) Phosphoramidite

configured for MerMade

• Synonyme(s) : DMT-2’O-TBDMS-rA(bz) Amidite, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-adenosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• Formule empirique (notation de Hill) : C₅₃H₆₆N₇O₈PSi
• Numéro CAS: 104992-55-4
• Poids moléculaire : 988.19
• Numéro MDL: MFCD00080297
• Code UNSPSC : 12352200
• ID de substance PubChem : 329770735
• Nomenclature NACRES : NA.51

Propriétés

• Source biologique: non-animal source (no BSE/TSE risk)
• Niveau de qualité: 300
• Gamme de produits: Proligo Reagents
• Essai: ≥99% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
• Forme: powder
• Technique(s): oligo synthesis: suitable
• Impuretés: ≤0.3% water content (Karl Fischer); ≤0.5% P(III) Impurities 100-169ppm (³¹P-NMR); ≤0.5% single Impurity (reversed phase HPLC); ≤3% residual Solvent content
• Couleur: white to off-white
• λ: conforms (UV/VIS Identity)
• Adéquation: conforms to structure for H-NMR; conforms to structure for LC-MS
• Compatibilité: configured for MerMade
• Profil des nucléosides: base: adenosine; base protecting group: benzoyl; 2' protecting group: TBDMS; 5' protecting group: DMT; deprotection: standard
• Température de stockage: −20°C
• Chaîne SMILES: COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)c5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7
• InChI: 1S/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/m1/s1
• Clé InChI: FFXHNCNNHASXCT-RFMFGJHUSA-N

Description

Description générale

RNA phosphoramidites, along with RNA CPG, and analogous to DNA synthesis support the synthesis of sequence-specific RNA oligonucleotides for RNA interference (RNAi) and can be used in target validation and other drug development techniques.Modern phosphoramidite-mediated synthesis has enabled routine high-yielding preparations of RNA oligonucleotides. High-quality RNA phosphoramidites are key to low failure rates, the high biological activity of synthesis products, and cost-effectiveness.Key Features

• Industry-standard 2′O-TBDMS protective group
• Consistent lot-to-lot purity and performance
• Compatible with deprotection methods based on methylamine or AMA
• Standard RNA phosphoramidites provide excellent coupling results whenused with ETT or BTT as an activator; best results are obtained withActivator 42®
• Capping with standard acetic anhydride capping reagent rather than withFast Deprotection Cap A
• Manufactured under a certified ISO 9001 quality systemDMT-2′O-TBDMS-rA(bz) Phosphoramidite is configured for MerMade Synthesizers.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable