A3262

Adenosine 3′,5′-cyclic monophosphate tris salt

Name: Adenosine 3′,5′-cyclic monophosphate tris salt
Brand: SIGMA
Price: 349 CHF

≥97% (HPLC), synthetic, powder

Synonyme(s) :

cAMP, cyclic AMP

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500 MG

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A propos de cet article

Formule empirique (notation de Hill) :

C₁₀H₁₂N₅O₆P · C₄H₁₁NO₃

Numéro CAS:

102029-77-6

Poids moléculaire :

450.34

Numéro MDL:

MFCD00058346

Code UNSPSC :

41106305

eCl@ss :

32160414

ID de substance PubChem :

329770822

Nomenclature NACRES :

NA.51

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Nom du produit

Adenosine 3′,5′-cyclic monophosphate tris salt, ≥97% (HPLC), powder

Source biologique

synthetic

Niveau de qualité

200

Essai

≥97% (HPLC)

Forme

powder

Couleur

white

Solubilité

H₂O: 100 mg/mL

Température de stockage

−20°C

Chaîne SMILES

NC(CO)(CO)CO.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O

InChI

1S/C10H12N5O6P.C4H11NO3/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;5-4(1-6,2-7)3-8/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);6-8H,1-3,5H2/t4-,6-,7-,10-;/m1./s1

Clé InChI

CLDDYJFNXTUHIN-MCDZGGTQSA-N

Catégories apparentées

Phosphates

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Cet article	A9376	A0386	A9501
Sigma-Aldrich A3262 Adenosine 3′,5′-cyclic monophosphate tris salt	Sigma-Aldrich A9376 Adenosine 2′:3′-cyclic monophosphate sodium salt	Sigma-Aldrich A0386 Adenosine 3′-monophosphate sodium salt	Sigma-Aldrich A9501 Adenosine 3′,5′-cyclic monophosphate
biological source synthetic	biological source synthetic (organic)	biological source yeast	biological source -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
assay ≥97% (HPLC)	assay ≥93%	assay ≥98% (HPLC)	assay ≥98.5% (HPLC)
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
color white	color -	color -	color white

Description générale

Adenosine 3′,5′-cyclic monophosphate (cAMP) is synthesized from ATP in the presence of Adenylate cyclase enzyme. cAMP is majorly used as a marker in immunochemical detection assays.[1] Intracellular levels of cAMP control immune and inflammatory functions. Bacterial infection triggers intracellular cAMP production.[2] Elevated levels of cAMP modulates mitogen-activated protein kinase (MAPK) in cancer. An altered cAMP level is implicated in pathogenesis of cataract and cardiovascular disease. A decrease in cAMP levels triggers impaired insulin secretion in diabetes.[3]

Application

Adenosine 3′,5′-cyclic monophosphate tris salt has been used as a medium supplement for human endometrial stromal cells (hESCs) culture[4] and induced neural stem cells (iNSCs).[5] It has been used in the spectroscopic characterization of pink flamindo, a red cAMP indicator.[6]

Actions biochimiques/physiologiques

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number

0000425160

0000364881

SLCF8554

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Targeted ablation of Wnt4 and Wnt5a in Müllerian duct mesenchyme impedes endometrial gland development and causes partial Müllerian agenesis.

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Cyclic AMP: master regulator of innate immune cell function

Serezani CH, et al.

American Journal of Respiratory Cell and Molecular Biology, 39(2), 127-132 (2008)

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Adenosine 3′,5′-cyclic monophosphate tris salt

≥97% (HPLC), synthetic, powder

Sélectionner une taille de conditionnement