B1760

Benzo[a]pyrène

Name: Benzo[<I>a</I>]pyrène
Brand: SIGMA
Price: 83.4 CHF

≥96% (HPLC)

Synonyme(s) :

3,4-benzpyrène, Benzo[def]chrysène

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83.40 CHF

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330.00 CHF

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599.00 CHF

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2 400.00 CHF

83.40 CHF

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₀H₁₂

Numéro CAS:

50-32-8

Poids moléculaire :

252.31

Beilstein:

1911333

Numéro CE :

200-028-5

Numéro MDL:

MFCD00003602

Code UNSPSC :

12352005

ID de substance PubChem :

24891610

Nomenclature NACRES :

NA.25

Principaux documents

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Niveau de qualité

200

Essai

≥96% (HPLC)

Forme

solid

pb

495 °C (lit.)

Pf

177-180 °C (lit.)

Chaîne SMILES

c1ccc2c(c1)cc3ccc4cccc5ccc2c3c45

InChI

1S/C20H12/c1-2-7-17-15(4-1)12-16-9-8-13-5-3-6-14-10-11-18(17)20(16)19(13)14/h1-12H

Clé InChI

FMMWHPNWAFZXNH-UHFFFAOYSA-N

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Cet article	ERMAC051	51968	48564
Sigma-Aldrich B1760 Benzo[a]pyrène	ERMAC051 Benzo[a]pyrène	Supelco 51968 Benzo[a]pyrène	Supelco 48564 Benzo[a]pyrène
assay ≥96% (HPLC)	assay -	assay -	assay -
form solid	form -	form -	form -
Quality Level 200	Quality Level -	Quality Level 300	Quality Level 100
bp 495 °C (lit.)	bp 495 °C (lit.)	bp 495 °C (lit.)	bp 495 °C (lit.)
mp 177-180 °C (lit.)	mp 177-180 °C (lit.)	mp 177-180 °C (lit.)	mp 177-180 °C (lit.)

Application

Benzo[a]pyrene (PAH), a polycyclic aromatic hydrocarbon pollutant, is used as a chemical carcinogen in experimental models of cancer. Carcinogenesis depends on it′s oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.

Produit(s) apparenté(s)

Réf. du produit

Description

Tarif

48564

Benzo[a]pyrène, analytical standard, for environmental analysis

Pictogrammes

GHS08,GHS07,GHS09

Mention d'avertissement

Danger

Mentions de danger

H317,H340,H350,H360FD,H410

Conseils de prudence

P202 - P261 - P273 - P280 - P302 + P352 - P308 + P313

Classification des risques

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Muta. 1B - Repr. 1B - Skin Sens. 1

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

0000491606

0000447312

0000474513

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Consulter la Bibliothèque de documents

Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene.

Ariel Revel et al.

Journal of applied toxicology : JAT, 23(4), 255-261 (2003-07-29)

Benzo[a]pyrene (BaP) is an agonistic ligand for the aryl hydrocarbon receptor (AhR) and a major environmental carcinogen implicated in the aetiology of lung cancer through the induction of benzo[a]pyrene diol epoxidation (BPDE) and BPDE-DNA adducts. Because BaP metabolization requires cytochrome

Integrated Hypoxia Signaling and Oxidative Stress in Developmental Neurotoxicity of Benzo[a]Pyrene in Zebrafish Embryos.

Yi-Chen Lin et al.

Antioxidants (Basel, Switzerland), 9(8) (2020-08-17)

Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon formed by the incomplete combustion of organic matter. Environmental B[a]P contamination poses a serious health risk to many organisms because the pollutant may negatively affect many physiological systems. As such, chronic exposure to

Antagonistic Interactions between Benzo[a]pyrene and Fullerene (C60) in Toxicological Response of Marine Mussels.

Audrey Barranger et al.

Nanomaterials (Basel, Switzerland), 9(7) (2019-07-11)

This study aimed to assess the ecotoxicological effects of the interaction of fullerene (C60) and benzo[a]pyrene (B[a]P) on the marine mussel, Mytilus galloprovincialis. The uptake of nC60, B[a]P and mixtures of nC60 and B[a]P into tissues was confirmed by Gas

beta-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists: improvement of solubility by disruption of molecular planarity.

Yuji Fujita et al.

Bioorganic & medicinal chemistry, 18(3), 1194-1203 (2010-01-12)

The physiological role of aryl hydrocarbon receptor (AhR) is not yet fully understood, and investigation is hampered by the limited solubility of reported AhR ligands in aqueous media. To achieve improved solubility, we focused on our previous finding that planarity-disruption

TIPE2 Induced the Proliferation, Survival, and Migration of Lung Cancer Cells Through Modulation of Akt/mTOR/NF-κB Signaling Cascade.

Devivasha Bordoloi et al.

Biomolecules, 9(12) (2019-12-11)

Lung cancer represents the most common cause of cancer deaths in the world, constituting around 11.6% of all new cancer cases and 18.4% of cancer-related deaths. The propensity for early spread, lack of suitable biomarkers for early diagnosis, as well

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Benzo[a]pyrène

≥96% (HPLC)