C2175

(Tyr[SO₃H]²⁷)Cholecystokinin fragment 26-33 Amide

≥97% (HPLC), powder

• Synonyme(s) : CCK-8, Cholecystokinin octapeptide, Pancreozymin C-terminal octapeptide, Sincalide
• Formule empirique (notation de Hill) : C₄₉H₆₂N₁₀O₁₆S₃
• Numéro CAS: 25126-32-3
• Poids moléculaire : 1143.27
• Beilstein: 5231801
• Numéro CE : 246-639-0
• Numéro MDL: MFCD00079849
• Code UNSPSC : 51111800
• ID de substance PubChem : 24892470
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 200
• Essai: ≥97% (HPLC)
• Forme: powder
• Numéro d'accès UniProt: P06307; P30551; P30553
• Température de stockage: −20°C
• Chaîne SMILES: CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NC(CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
• InChI: 1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35?,36-,37-,38-,39-/m0/s1
• Clé InChI: IZTQOLKUZKXIRV-IVVJSLGPSA-N
• Informations sur le gène: human ... CCK(885) ; rat ... Cckar(24889), Cckbr(25706)

Description

Amino Acid Sequence

Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2

Description générale

(Tyr[SO₃H]²⁷)Cholecystokinin fragment 26-33 amide is a sulfated cholecystokinin(CCK) octapeptide[1] derived from the proCCK.[2] It is present in plasma and endocrine cells.[2]

Application

(Tyr[SO₃H]²⁷)Cholecystokinin fragment 26-33 amide has been used to test its effects:

• to study its effects on β5i/LMP7 immunoproteasome subunit in pancreatitis[3]
• on gastric emptying,food intake and c-Fos immunoreactivity in small litter (SL) and normal litter (NL) rats[1]
• on the intestine and gallbladder motility in fish Ballan Wrasse[4]

Actions biochimiques/physiologiques

(Tyr[SO₃H]²⁷)Cholecystokinin fragment 26-33 amide activates the cholecystokinin type B receptor and may mediate the blockage of opioid analgesia.[5] It elicits anti-inflammatory effects. It mediates the inhibition on cytokine release, lymphocytes, and macrophages.[2]

Neurotransmitter; predominant form of CCK in CNS and gastrointestinal tract; may play a role in satiety.

Autres remarques

C-Terminal octapeptide of cholecystokinin

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)