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Merck

L7877

Lactulose

≥95% (HPLC)

Synonyme(s) :

4-O-β-D-Galactopyranosyl-D-fructofuranose, 4-O-β-D-Galactopyranosyl-D-fructose

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A propos de cet article

Formule empirique (notation de Hill) :
C12H22O11
Numéro CAS:
4618-18-2
Poids moléculaire :
342.30
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
24896485
EC Number:
225-027-7
Beilstein/REAXYS Number:
93773
MDL number:
MFCD00151469

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Nom du produit

Lactulose, ≥95% (HPLC)

InChI key

JCQLYHFGKNRPGE-WJONTELPSA-N

InChI

1S/C12H22O11/c13-1-4-6(16)7(17)8(18)11(21-4)22-9-5(2-14)23-12(20,3-15)10(9)19/h4-11,13-20H,1-3H2/t4-,5-,6+,7+,8-,9-,10+,11+,12+/m1/s1

SMILES string

OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@@](O)(CO)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O

biological source

synthetic

assay

≥95% (HPLC)

form

powder

optical activity

[α]20/D -52.0 to -48.0 °, c = 4% (w/v) in water

color

white to off-white

mp

169  °C ((336 °F ))

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

room temp

Quality Level

200

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Cet article
BP210L0130000427584
Lactulose ≥95% (HPLC)

Sigma-Aldrich

L7877

Lactulose

Lactulose British Pharmacopoeia (BP) Reference Standard

BP210

Lactulose

Lactulose European Pharmacopoeia (EP) Reference Standard

L0130000

Lactulose

Lactulose A β-galactosidase substrate.

Millipore

427584

Lactulose

assay

≥95% (HPLC)

assay

-

assay

-

assay

≥97% (HPLC)

biological source

synthetic

biological source

-

biological source

-

biological source

-

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

-

solubility

-

solubility

water: 10 mg/mL

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

100

form

powder

form

solid

form

-

form

solid

storage temp.

room temp

storage temp.

2-8°C

storage temp.

-

storage temp.

15-25°C

Biochem/physiol Actions

Lactulose is a synthetic disaccharide derived from galactose and fructose. It is not absorbed in the gut and is frequently used in the treatment of constipation and hepatic encephalopathy. Studies have reported that lactulose administration may cause an increase in fecal nitrogen. It is also known to function as a prebiotic. Lactulose measurements can be used to detect gastrointestinal dysfunctions.

Other Notes

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Classe de stockage

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000484918
0000484918
0000486766
0000486766
0000479458

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Huifang Yin et al.
Carbohydrate research, 465, 58-65 (2018-06-27)
Oligosaccharides derived from lactulose (β-D-Galp-(1 → 4)-D-Fru) are drawing more and more attention nowadays because of their strong resistance to gut digestion, and the interest to discover novel prebiotics. Compared to galactooligosaccharides, currently known structures of lactulose oligosaccharides are very limited. In
Tara Raftery et al.
United European gastroenterology journal, 3(3), 294-302 (2015-07-03)
Vitamin D (vitD) supplementation may prolong remission in Crohn's disease (CD); however, the clinical efficacy and mechanisms are unclear. To determine changes in intestinal permeability (IP), antimicrobial peptide (AMP) concentrations and disease markers in CD, in response to vitD supplementation.
Edwin R Price et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 164(2), 351-355 (2012-11-21)
Flying vertebrates have been hypothesized to have a high capacity for paracellular absorption of nutrients. This could be due to high permeability of the intestines to nutrient-sized molecules (i.e., in the size range of amino acids and glucose, MW 75-180
J Zhao et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(6), 794-802 (2014-03-20)
Small intestinal bacterial overgrowth (SIBO) may be a cause of irritable bowel syndrome (IBS); however, current investigations have important limitations. We aimed to identify clinically relevant diagnostic criteria for SIBO based on lactulose hydrogen breath test (LHBT) alone and combined
C P Kelly et al.
Alimentary pharmacology & therapeutics, 37(2), 252-262 (2012-11-21)
Coeliac disease, an autoimmune disorder triggered by gluten ingestion, is managed by a gluten-free diet (GFD), which is difficult for many patients. Larazotide acetate is a first-in-class oral peptide that prevents tight junction opening, and may reduce gluten uptake and
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