Accéder au contenu
Merck

M9281

3-Methyladenine

≥99% (HPLC), synthetic (organic), powder

Synonyme(s) :

3-MA, 6-Amino-3-methylpurine

Slide 1 of 3
Se connecter pour consulter les tarifs organisationnels et contractuels.

Sélectionner une taille de conditionnement

100 MG

336.00 CHF

500 MG

721.00 CHF

336.00 CHF

Vérifier la disponibilité des articles du panier

A propos de cet article

Formule empirique (notation de Hill) :
C6H7N5
Numéro CAS:
5142-23-4
Poids moléculaire :
149.15
NACRES:
NA.51
PubChem Substance ID:
24897326
UNSPSC Code:
41106305
EC Number:
225-908-6
MDL number:
MFCD00010531
Beilstein/REAXYS Number:
146087

Principaux documents

Voir toute la documentation

Passer à

Service technique
Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.
Laissez-nous vous aider

Nom du produit

3-Methyladenine, autophagy inhibitor

InChI

1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3

InChI key

FSASIHFSFGAIJM-UHFFFAOYSA-N

SMILES string

Cn1cnc(N)c2ncnc12

biological source

synthetic (organic)

assay

≥99% (HPLC)

form

powder

mp

~300 °C (dec.) (lit.)

solubility

DMF: 9.80-10.20 mg/mL, clear, colorless to light yellow

storage temp.

room temp

Quality Level

300

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Catégories apparentées

Comparer avec des articles similaires

Voir la comparaison complète

Montrer les différences

1 of 4

Cet article
66654867074E4267
3-Methyladenine autophagy inhibitor

Sigma-Aldrich

M9281

3-Methyladenine

7-Methyladenine 97%

Sigma-Aldrich

666548

7-Methyladenine

9-Methylguanine ≥98.0% (HPLC)

Sigma-Aldrich

67074

9-Methylguanine

9-Ethylguanine

Sigma-Aldrich

E4267

9-Ethylguanine

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

Quality Level

300

Quality Level

200

Quality Level

100

Quality Level

200

form

powder

form

solid

form

-

form

powder

assay

≥99% (HPLC)

assay

97%

assay

≥98.0% (HPLC)

assay

≥98%

solubility

DMF: 9.80-10.20 mg/mL, clear, colorless to light yellow

solubility

-

solubility

-

solubility

1 M NaOH: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

mp

~300 °C (dec.) (lit.)

mp

346-350 °C

mp

≥300 °C

mp

-

Application

3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.
3-Methyladenine has been used as an autophagy inhibitor:
  • to determine the expressions of autophagy-related genes (Beclin 1, light chain 3 (LC3) and p62) using the transfected human bone marrow mesenchymal stem cells (BM-MSCs)[1]
  • with cisplatin to study the inhibition of autophagy influenced cisplatin-induced apoptosis in A2780cp cells[2]
  • to study the interplay between colistin-induced autophagy and apoptosis[3]

Standard for detection of nucleic acid methylation during carcinogenesis.

Biochem/physiol Actions

3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III phosphatidylinositol 3-kinases (PI-3K).[4]

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Preparation Note

This product is soluble in DMF (10 mg/mL; may require gentle heating). It is also soluble in water, 95% ethanol, or 1 N NaOH at 30 mg/mL with heating, but upon cooling, the product precipitates from solution. Solutions of 3-MA may be prepared in DMSO at 100 mM.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
0000207629
0000192625
0000475686
0000475686
0000457318

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Rechercher un(e) COA

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Jingyuan Chen et al.
Shock (Augusta, Ga.), 52(1), 111-121 (2018-10-05)
Sepsis-induced myopathy is a heavy burden for patients during respiratory failure as well as after discharge, which could be characterized with qualitative changes to nAChR in a rat model of sepsis, regulated by NRG-1. Autophagy is an innate immune defense
Ruishuang Ma et al.
Cancer biology & therapy, 20(9), 1206-1212 (2019-05-17)
Autophagy plays a complicated role in tumorigenesis, and the effects of autophagy in drug resistance have not been fully known. The aim of this study was to evaluate autophagy activity in lung cancer cells derived from different origins and explore
Heng Wang et al.
Journal of dairy science, 102(9), 8264-8272 (2019-07-01)
Staphylococcus aureus is an important pathogen causing chronic and subclinical mastitis of cows. Autophagy is an important regulatory mechanism that participates in the elimination of invading pathogenic organisms. Here, we hypothesize that autophagy is involved in the process of Staph.
Xiao Ye et al.
Peptides, 119, 170120-170120 (2019-07-28)
Insulin resistance (IR) is a fundamental pathogenic factor shared by a myriad of metabolic disorders, including obesity and type 2 diabetes. The mechanism of IR is usually accompanied by mitochondrial dysfunction. Irisin has been proposed to act as a hormone
Shuyan Wang et al.
Cell transplantation, 28(6), 775-782 (2019-01-23)
Astrocytes protection and functional regulation are important strategies to protect against neuronal damage caused by ischemia. Activation of the delta opioid receptor (DOR) could reduce astrocytes damage, although the mechanism remains unclear. The present study aimed to test the effect
Afficher tous les articles scientifiques apparentés

Articles

Autophagy in Cancer Promotes Therapeutic Resistance

We presents an article on Autophagy in Cancer Promotes Therapeutic Resistance

Fluorescent Live Cell Imaging of LC3 Mediated Autophagy using LentiBrite™ Lentiviral Biosensors

High titer lentiviral particles for LC3 variants used for live cell analysis of cellular autophagy.

Questions

Reviews

No rating value

Active Filters

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique