08-115

Rat Collagen Type I

from rat tail, liquid, 2-5 mg/mL, suitable for cell culture, used for 3D gel formation

• Sinonimo/i: Collagene di coda di topo, Collagene di tipo I di coda di topo
• UNSPSC Code: 12352202
• eCl@ss: 32160405
• NACRES: NA.75
• Biological source: rat
• Form: liquid, solution
• Technique(s): cell culture | mammalian: suitable (and for 3D proliferation assays.)
• Concentration: 100 mg

Proprietà

• Nome del prodotto: Collagen Type I, rat tail, 100 mg, solution, BioReagent, suitable for cell culture
• biological source: rat
• Quality Segment: 100
• form: liquid, solution
• manufacturer/tradename: Upstate^®
• concentration: 100 mg
• technique(s): cell culture | mammalian: suitable (and for 3D proliferation assays.)
• input: sample type hematopoietic stem cell(s); sample type mesenchymal stem cell(s); sample type induced pluripotent stem cell(s); sample type epithelial cells; sample type pancreatic stem cell(s); sample type neural stem cell(s); sample type: mouse embryonic stem cell(s)
• NCBI accession no.: NM_000088.3
• UniProt accession no.: P02452
• shipped in: wet ice
• storage temp.: 2-8°C
• Gene Information: rat ... COL1A1(29393)

Descrizione

General description

In humans, type I collagen is the most abundant and broadly expressed collagen. This heterotrimer contains two alpha 1 (I) chains and one alpha 2 (I) chain. αα It has repeating Gly-Xaa-Yaa tri-peptides motifs. The collagen alpha-1(I) chain protein is a member of the collagen complex superfamily. COL1A1 has a von Willebrand factor type C (vWFC) domain, a collagen triple-helix repeat, and a fibrillar collagen C-terminal domain (COLF).

Application

Biochem/physiol Actions

α It is involved in carboplatin-resistant ovarian cancer (OV). COL1A1 serves as an oncogene in the development of colorectal cancer (CRC). Dominant inherited COL1A1 gene mutations result in connective tissue disorders such as osteogenesis imperfecta (OI).

Physical form

0.02N acetic acid, pH 3.67

Preparation Note

1 anno a 4°C

Analysis Note

Routinely evaluated by testing for uniform gelation and for attachment of and spreading of PC-12 rat cells

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Salvo diversa indicazione nel nostro catalogo o in altra documentazione fornita dall′azienda insieme al prodotto, i nostri prodotti sono destinati esclusivamente a scopi di ricerca e non devono essere utilizzati per altre finalità, inclusi a titolo esemplificativo ma non esaustivo, fini commerciali non autorizzati, applicazioni diagnostiche in vitro, usi terapeutici ex vivo o in vivo o qualsiasi altro tipo di assunzione o applicazione rivolta agli esseri umani o agli animali.

Informazioni sulla sicurezza

• Classe di stoccaggio: 12 - Non Combustible Liquids
• WGK: WGK 1