DPP4-M

Inibitore DPP IV

• Sinonimo/i: Gliptine
• UNSPSC Code: 41116012
• NACRES: NC.07
• eCl@ss: 32160405

Proprietà

• form: solution
• Quality Segment: 100
• NCBI accession no.: NM_001935.3
• UniProt accession no.: P27487
• Gene Information: human ... DPP4(1803)

Descrizione

General description

Dipeptidyl peptidase IV (DPP IV), a dimeric type II integral membrane glycoprotein, is a member of the family of prolyl-specific proteases. It is abundantly expressed in the epithelial and nonepithelial tissues. It is highly expressed in the kidney and the colon.

Application

Categoria della ricerca
Tutte

Biochem/physiol Actions

Dipeptidyl peptidase IV (DPP IV) controls insulin-stimulating hormones, glucagon-like peptide (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP). ′ In addition to its catalytic action, DPP-4 also serves as a binding protein and a ligand of extracellular factors. DPP-4 inhibition causes GLP-1 and GIP to have a prolonged activity, hence DPP-4 inhibitors help maintain glucose homeostasis. DPP IV inhibitors can improve glycemic control for a longer period when compared to early oral hypoglycemics.

Preparation Note

Conservare a 4°C subito alla consegna. Per la conservazione oltre due settimane, si consiglia di conservare a –20°C.