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DPP4-M

Inibitore DPP IV

Sinonimo/i:

Gliptine

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1 mL
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CHF 127.00
10 mL
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CHF 987.00

Informazioni su questo articolo

UNSPSC Code:
41116012
NACRES:
NC.07
eCl@ss:
32160405

CHF 127.00

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form

solution

Quality Segment

NCBI accession no.

UniProt accession no.

Gene Information

human ... DPP4(1803)

General description

Dipeptidyl peptidase IV (DPP IV), a dimeric type II integral membrane glycoprotein, is a member of the family of prolyl-specific proteases. It is abundantly expressed in the epithelial and nonepithelial tissues. It is highly expressed in the kidney and the colon.

Application

Categoria della ricerca
Tutte

Biochem/physiol Actions

Dipeptidyl peptidase IV (DPP IV) controls insulin-stimulating hormones, glucagon-like peptide (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP). ′ In addition to its catalytic action, DPP-4 also serves as a binding protein and a ligand of extracellular factors. DPP-4 inhibition causes GLP-1 and GIP to have a prolonged activity, hence DPP-4 inhibitors help maintain glucose homeostasis. DPP IV inhibitors can improve glycemic control for a longer period when compared to early oral hypoglycemics.

Preparation Note

Conservare a 4°C subito alla consegna. Per la conservazione oltre due settimane, si consiglia di conservare a –20°C.

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Questions

1–3 of 3 Questions  

  1. What is the stability of this compound at 4C? How many freeze thaws can it tolerate?

    1 answer

    1. This product is stable in 4 degree C for at least 2 weeks. Freeze-thaw cycles should be kept to a minimum. Up to three cycles have been performed without any detectable loss of activity. To further protect product integrity, aliquoting the material is recommended to avoid repeated freezing and thawing. Please see the link below to review additional information available in the product datasheet:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/991/950/dpp4-insert.pdf

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  2. Would our lab be able to store this product at -80 degrees celsius without compromising its composition? 

    1 answer

    1. It is recommended to store this product at -20°C. The long term stability of this product at -80°C has not been determined. However, there are no issues anticipated by storing this material at ultra-low temperatures.

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  3. What is the concentration of this product and what is the working concentration suggested? Thanks!

    1 answer

    1. This product as provided at a concentration of 4 mM. The working concentration recommendations are 10 μl/mL of whole blood or 20 μl/mL of buffer, plasma, serum, or tissue culture medium. These are general usage recommendations, the optimal concentration is application- and/or system-dependent. The final working concentration should be empirically determined by the end user.

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