MABE415
Anti-FoxP2 Antibody, clone FOXP2-73A/8
clone FOXP2-73A/8, from mouse
Sinonimo/i:
Forkhead box protein P2, CAG repeat protein 44, Trinucleotide repeat-containing gene 10 protein
Autenticati per visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Scegli un formato
Prezzi e disponibilità al momento non sono disponibili
Informazioni su questo articolo
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Vai a
Servizio Tecnico
Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.
Permettici di aiutartiOrigine biologica
mouse
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
FOXP2-73A/8, monoclonal
Reattività contro le specie
human
tecniche
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Isotipo
IgG1κ
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... FOXP2(93986)
1 of 4
Questo articolo | ABE73 | ABE68 | ABE1828 |
|---|---|---|---|
| Gene Information human ... FOXP2(93986) | Gene Information human ... FOXP2(93986) | Gene Information human ... FOXP1(27086) | Gene Information human ... FOXK2(3607) |
| species reactivity human | species reactivity rabbit, human, mouse | species reactivity human, mouse | species reactivity human |
| biological source mouse | biological source rabbit | biological source rabbit | biological source rabbit |
| antibody form purified immunoglobulin | antibody form serum | antibody form serum | antibody form serum |
| clone FOXP2-73A/8, monoclonal | clone polyclonal | clone polyclonal | clone polyclonal |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
Descrizione generale
Forkhead box protein P2 (FoxP2) is a multidomain transcriptional repressor that belongs to the Fox family of proteins. The FoxP2 protein contains a forkhead-box DNA-binding domain, characteristic of the FOX group of transcription factors. In addition, this protein contains a polyglutamine tract, as well as zinc finger and leucine zipper motifs. In order for FoxP2 to bind DNA, it forms homodimers and heterodimers with FoxP1 and FoxP4. The forkhead box family of proteins play an important role in immune response, organ development and the development of cancer. Functional studies in vertebrates suggest this gene plays a role in the modulation of neural plasticity. In line with these findings, mutations of FoxP2 in humans have been linked to speech and language disorders.
~80 kDa observed. Uniprot describes 9 isoforms between 9-83 kDa
Immunogeno
GST-tagged recombinant protein corresponding to the N-terminus of Human FoxP2.
Applicazioni
Detect FOXP2 using this mouse monoclonal antibody, Anti-FoxP2 Antibody, clone FOXP2-73A/8 validated for use in western blotting & IHC.
Western Blotting Analysis: 1 µg/mL from a representative lot detected FoxP2 in 10 µg of THP-1 cell lysate.
Immunoprecipitation Analysis (IP): A representative lot of this antibody was demonstrated to immunoprecipitate FoxP2 using growth arrested 143B cells (Gascoyne D.M., et al. (2015). PLoS One, 10(6):e0128513).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected FoxP2 in human tonsil tissues (Campbell, A. J., et al. (2010). Br J Haematol. 149(2):221-230.).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected FoxP2 in proliferating chondrocytes of murine E17.5 long bone (Gascoyne D.M., et al. (2015). PLoS One, 10(6):e0128513).
Immunoprecipitation Analysis (IP): A representative lot of this antibody was demonstrated to immunoprecipitate FoxP2 using growth arrested 143B cells (Gascoyne D.M., et al. (2015). PLoS One, 10(6):e0128513).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected FoxP2 in human tonsil tissues (Campbell, A. J., et al. (2010). Br J Haematol. 149(2):221-230.).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected FoxP2 in proliferating chondrocytes of murine E17.5 long bone (Gascoyne D.M., et al. (2015). PLoS One, 10(6):e0128513).
Azioni biochim/fisiol
This antibody recognizes FoxP2 isoforms at 70 kDa, 48 kDa, and 40 kDa.
Stato fisico
Format: Purified
Risultati analitici
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected FoxP2 in 10 µg of HeLa cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected FoxP2 in 10 µg of HeLa cell lysate.
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Non trovi il prodotto giusto?
Prova il nostro Motore di ricerca dei prodotti.
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Pedro M Rodenas-Cuadrado et al.
The Journal of comparative neurology, 526(8), 1235-1266 (2018-01-04)
Genes including FOXP2, FOXP1, and CNTNAP2, have been implicated in human speech and language phenotypes, pointing to a role in the development of normal language-related circuitry in the brain. Although speech and language are unique to humans a comparative approach
Ayla Aksoy-Aksel et al.
eLife, 10 (2021-05-25)
Dopaminergic signaling plays an important role in associative learning, including fear and extinction learning. Dopaminergic midbrain neurons encode prediction error-like signals when threats differ from expectations. Within the amygdala, GABAergic intercalated cell (ITC) clusters receive one of the densest dopaminergic
Boglárka Barsy et al.
Nature neuroscience, 23(5), 625-637 (2020-04-15)
Decades of research support the idea that associations between a conditioned stimulus (CS) and an unconditioned stimulus (US) are encoded in the lateral amygdala (LA) during fear learning. However, direct proof for the sources of CS and US information is
Takako Kita et al.
The European journal of neuroscience, 44(11), 2899-2908 (2016-10-08)
Projections from the posterior intralaminar thalamic nuclei and the superior colliculus (SC) to the subthalamic nucleus (STN) and the zona incerta (ZI) have been described in the primate and rodent. The aims of this study was to investigate several questions
Xiaoquan Zhu et al.
eLife, 12 (2023-09-05)
Identification oncogenes is fundamental to revealing the molecular basis of cancer. Here, we found that FOXP2 is overexpressed in human prostate cancer cells and prostate tumors, but its expression is absent in normal prostate epithelial cells and low in benign
Active Filters
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica