A6933

Acetyl-Amyloid β-Protein Fragment 15-20 Amide

≥97% (HPLC), powder

• Sinonimo/i: Ac-QKLVFF-NH₂, amyloid blocker
• Formula empirica (notazione di Hill): C₄₂H₆₃N₉O₈
• Numero CAS: 189064-06-0
• Peso molecolare: 822.01
• NACRES: NA.32
• PubChem Substance ID: 329770908
• UNSPSC Code: 12352202
• MDL number: MFCD17215285
• Form: powder
• Assay: ≥97% (HPLC)

Proprietà

• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: powder
• color: white
• UniProt accession no.: P05067
• storage temp.: −20°C
• SMILES string: CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(N)=O
• InChI: 1S/C42H63N9O8/c1-25(2)22-33(49-38(55)30(18-12-13-21-43)47-39(56)31(46-27(5)52)19-20-35(44)53)41(58)51-36(26(3)4)42(59)50-34(24-29-16-10-7-11-17-29)40(57)48-32(37(45)54)23-28-14-8-6-9-15-28/h6-11,14-17,25-26,30-34,36H,12-13,18-24,43H2,1-5H3,(H2,44,53)(H2,45,54)(H,46,52)(H,47,56)(H,48,57)(H,49,55)(H,50,59)(H,51,58)/t30-,31-,32-,33-,34-,36-/m0/s1
• InChI key: DDXTVYDSGCHGAN-PITCCTKHSA-N
• Gene Information: human ... APP(351)

Descrizione

Biochem/physiol Actions

Amyloid plaques characteristic of the Alzheimer brain contain fibrils composed of amyloid beta aggregates. Short peptides containing the sequence KLVFF have been shown to bind specifically to the homologous region in Aβ and are used to prevent full length amyloid fibril formation.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• WGK: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable
• DPI (dispositivi di protezione individuale): Eyeshields, Gloves, type N95 (US)