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E3763

Resorufin ethyl ether

≥98% (TLC), CXPIA1/2 substrate, powder

Sinonimo/i:

7-Ethoxy-3H-phenoxazin-3-one, Ethoxyresorufin, O7-Ethylresorufin

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Cambia visualizzazione
Voi/SKUDisponibilitàPrezzo
1 mg
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CHF 137.00
5 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 328.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C14H11NO3
Numero CAS:
Peso molecolare:
241.24
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
Beilstein/REAXYS Number:
225973

CHF 137.00


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Nome del prodotto

Resorufin ethyl ether, ≥98% (TLC), powder

Quality Segment

assay

≥98% (TLC)

form

powder

storage condition

(Tightly closed. Dry)

technique(s)

activity assay: suitable

color

orange to red

mp

223-225 °C (lit.)

solubility

chloroform: 9.80-10.20 mg/mL, clear, orange

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

CCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1.Fc4c(F)c(F)c(OC(=O)CNC(=O)OCC5c6ccccc6-c7ccccc57)c(F)c4F

InChI

1S/C23H14F5NO4.C14H11NO3/c24-17-18(25)20(27)22(21(28)19(17)26)33-16(30)9-29-23(31)32-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15;1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h1-8,15H,9-10H2,(H,29,31);3-8H,2H2,1H3

InChI key

ZOSYTBPPLWBBKM-UHFFFAOYSA-N

General description

Resorufin ethers are used as markers or substrates for different cytochrome P (CYP) isoforms. Resorufin ethyl ether is the preferred resorufin ether to be metabolized by microsomes of 3-methylcholanthrene treated animals.
Fluorimetric substrate for cytochrome P450 linked enzyme, CXPIA1/2
Resorufin is the reduced product of resazurin, also termed as Alamar Blu. It exhibits fluorescence at longer wavelengths and is flexible for modification in its hydroxyl group.

Research area: Cell Signaling

Application

Resorufin ethyl ether is suitable for the study of dealkylating activity of cytochrome P450 isozymes 1A1 and 1A2, where arylalkyl and alkyl isothiocyanates, and their glutathione, cysteine, and A′-acetylcysteine conjugates are used as inhibitors. It is suitable to study the ethoxyresorufin-O-deethylase (EROD) activity of cytochrome P450 activity (CYP1A1).

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Questo articolo
46121R3257B1532
description

≥98% (TLC), powder

description

suitable for fluorescence, ≥95% (UV)

description

redox indicator

description

CYP450 substrate

assay

≥98% (TLC)

assay

≥95% (UV)

assay

-

assay

≥98% (TLC)

solubility

chloroform: 9.80-10.20 mg/mL, clear, orange

solubility

DMF: soluble, DMSO: soluble, alcohols: soluble

solubility

water: 1 mg/mL, opaque

solubility

chloroform: 9.80-10.20 mg/mL, clear, orange

suitability

suitable for fluorescence

suitability

suitable for fluorescence

suitability

-

suitability

-

technique(s)

activity assay: suitable

technique(s)

protein detection: suitable

technique(s)

-

technique(s)

-

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

200

form

powder

form

solid

form

powder

form

powder


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Classe di stoccaggio

11 - Combustible Solids

Che succede?

WGK 3

Punto di infiammabilità (°F)

Not applicable

Punto di infiammabilità (°C)

Not applicable

DPI (dispositivi di protezione individuale)

Eyeshields, Gloves, type N95 (US)



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Questions

  1. What is the solution stability of E3763?

    1 answer
    1. It is recommended to prepare solutions fresh.

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