F6754
Ferritin from human liver
Type IV, 10 μg/mL
Autenticati per visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Scegli un formato
1 VIAL
CHF 289.00
Informazioni su questo articolo
Vai a
Servizio Tecnico
Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.
Permettici di aiutartiOrigine biologica
human liver
Livello qualitativo
Sterilità
0.2 μm filtered
Tipo
Type IV
Saggio
≥95% (SDS-GE)
Stato
liquid
PM
H subunit ~21 kDa
L subunit ~19 kDa
~440 kDa (a shell of 24 protein subunits (apoferritin) and a core of Fe3+ ions)
Confezionamento
vial of 2 μg
Concentrazione
10 μg/mL
Temperatura di conservazione
2-8°C
Informazioni sul gene
human ... FTH1(2495), FTL(2512), FTMT(94033)
1 of 4
Questo articolo | F6879 | F7879 | V8379 |
|---|---|---|---|
| biological source human liver | biological source human spleen | biological source horse spleen | biological source human plasma |
| assay ≥95% (SDS-GE) | assay - | assay - | assay - |
| concentration 10 μg/mL | concentration 10 μg/mL in 0.15 M NaCl, 10 mM Tris, pH 8.0, containing 0.1% sodium azide | concentration 10 mg/mL in 0.15 M NaCl | concentration - |
| mol wt H subunit ~21 kDa, ~440 kDa (a shell of 24 protein subunits (apoferritin) and a core of Fe3+ ions), L subunit ~19 kDa | mol wt - | mol wt - | mol wt A subunit 75 kDa, B subunit 65 kDa |
| form liquid | form liquid | form liquid | form lyophilized powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
Descrizione generale
Ferritin comprises 24-subunit and belongs to the ferritin-like diiron-carboxylate protein superfamily.[1] Ferritin exists as heavy (H) and light (L) subunits. Liver ferritin is majorly L subunit and the spleen has the H submit.[2] The L subunit is mapped to human chromosome 9q13.33[3] and the H subunit 11q12.3.[4]
Applicazioni
Ferritin from human liver has been used as model protein in size-exclusion high-performance liquid chromatography technique and for synthetic nanopore translocation studies.[5] It has also been used to test its effect on the susceptibility of shrimp (Litopenaeus vannamei) to the white spot syndrome virus.[1]
Azioni biochim/fisiol
A ubiquitous iron storage protein that plays a key role in iron metabolism. It serves as an intracellular iron reserve (particularly in spleen, liver, intestinal mucosa, and bone marrow) and functions in iron detoxification.
A ubiquitous iron storage protein that plays a key role in iron metabolism. It serves as an intracellular iron reserve (particularly in spleen, liver, intestinal mucosa, and bone marrow) and functions in iron detoxification. Studies have shown that ferritin iron incorporation is mediated by a ferroxidase activity associated with ferritin H subunits and a nucleation center associated with ferritin L subunits. Release of iron from ferritin has an essential role in iron-dependent lipid peroxidation and may contribute to free radical-induced cell damage in vivo. Therefore, by binding iron, ferritin may function as an antioxidant.
Ferritins are part of the host defense system and play a role in response to viral infection in animals.[1] The abnormal levels of ferritin are correlated to many tumors associated with the prostate, breast and brain.[6] High levels of ferritin are implicated in inflammation[6] and macrophage activation syndrome (MAS).[7] Mutations in the light subunit chain can lead to the neurodegenerative disease, hereditary ferritinopathy.[3]
Stato fisico
Solution in 10 mM Tris, 150 mM NaCl, pH 8.0, and 0.1% sodium azide.
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Alexander Michael Dohnal et al.
International journal of cancer, 119(12), 2870-2877 (2006-10-04)
The potential immunogenicity of acute lymphoblastic leukemia of the T cell (T-ALL), a small subgroup of childhood leukemia with increased risk for treatment failure and early relapse, was addressed by serological identification of leukemia-derived antigens by recombinant expression cloning (SEREX).
Huimei Huang et al.
Medical science monitor : international medical journal of experimental and clinical research, 25, 3700-3715 (2019-05-20)
BACKGROUND Serum ferritin is a useful tumor marker for renal cell carcinoma (RCC). However, the expression of ferritin heavy chain (FTH1), the main subunit of ferritin, is unclear in primary RCC tissues. In this study, we investigated FTH1 mRNA expression
A novel FTL mutation responsible for neuroferritinopathy with asymmetric clinical features and brain anomalies.
Sébastien Moutton et al.
Parkinsonism & related disorders, 20(8), 935-937 (2014-06-08)
Erik R Anderson et al.
Comprehensive Physiology, 3(1), 315-330 (2013-05-31)
Iron is an essential nutrient that is tightly regulated. A principal function of the liver is the regulation of iron homeostasis. The liver senses changes in systemic iron requirements and can regulate iron concentrations in a robust and rapid manner.
Yuan-Hwa Ruan et al.
Fish & shellfish immunology, 28(4), 542-548 (2010-01-05)
We examined the physiological (hemolymph glucose, lactate, and lipid) and innate non-specific immune responses (total hemocyte count (THC), phenoloxidase (PO) activity, respiratory bursts (release of superoxide anion, O(2)(-)) and superoxide dismutase (SOD) activity) to white spot syndrome virus (WSSV) in
Active Filters
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica