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MSQC8

SigmaMAb Antibody Drug Conjugate (ADC) Mimic

Antibody Cysteine-Fluorophore Conjugate Standard

Sinonimo/i:

Antibody Drug Conjugate

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Voi/SKUDisponibilitàPrezzo
0.5 mg
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CHF 699.00

Informazioni su questo articolo

NACRES:
NA.32
UNSPSC Code:
12352204
eCl@ss:
32160702
Technique(s):
protein mass spectrometry: suitable
Species reactivity:
-
Application:
protein mass spectrometry
Citations:
-

CHF 699.00

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recombinant

expressed in CHO cells

Quality Segment

antibody product type

primary antibodies

form

lyophilized powder

technique(s)

protein mass spectrometry: suitable

shipped in

wet ice

storage temp.

−20°C

General description

SigmaMab Antibody Drug Conjugate (ADC) Mimic, is a non-toxic drug mimic that is utilized as a standard for mass spectrometry and high performance liquid chromatography. The ADC Mimic conjugates SigmaMab (MSQC4), an IgG1 monoclonal antibody, to dansyl fluorophores via an LC-SMCC crosslinker. This dansyl-LC-SMCC attachment serves as the substitution for the toxic payload of a real ADC.

The ADC Mimic allows for safer and more consistent testing, making it the optimal product over real ADCs. It is also a more affordable product compared to real ADCs. With the help of this non-toxic product, LC-MS processes can be developed in a safer environment.

Application

Poster: Antibody Drug Conjugate Mimic Enables LC-MS Method Development Without Risk

Poster: LC-UV-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC-Mimic

Poster: LC-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC Mimic

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Questo articolo
MSQC4ADCDT010G32ADCMXRJ500TL
SigmaMAb Antibody Drug Conjugate (ADC) Mimic Antibody Cysteine-Fluorophore Conjugate Standard

Sigma-Aldrich

MSQC8

SigmaMAb Antibody Drug Conjugate (ADC) Mimic

SILu™Lite SigmaMAb Universal Antibody Standard human

Sigma-Aldrich

MSQC4

SILu™Lite SigmaMAb Universal Antibody Standard human

vibrant-m

ADCDT010G32

Mobius® ADC Reactor Single-Use Dip Tube

vibrant-m

ADCMXRJ500TL

Mobius® ADC Reactor 500L Carrier

description

Antibody Cysteine-Fluorophore Conjugate Standard

description

-

description

Gold, 10 L, 1/8" tubing

description

Stainless Steel Jacketed Carrier with Temperature Sensor and Load Cells

technique(s)

protein mass spectrometry: suitable

technique(s)

protein mass spectrometry: suitable

technique(s)

-

technique(s)

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

10-30°C

storage temp.

-

shipped in

wet ice

shipped in

wet ice

shipped in

-

shipped in

-

form

lyophilized powder

form

-

form

-

form

-

Quality Level

200

Quality Level

200

Quality Level

400

Quality Level

EQ4

recombinant

expressed in CHO cells

recombinant

expressed in CHO cells

recombinant

-

recombinant

-

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WGK

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Questions

1–3 of 3 Questions  

  1. Is the primary sequence of the antibody available?

    1 answer

    1. SigmaMAb Antibody Drug Conjugate (ADC) Mimic consists of the human universal monoclonal antibody standard (Catalog Number MSQC4, an IgG1 monoclonal antibody) conjugated to dansyl fluorophores via an LC-SMCC crosslinker.

      The sequence of MSQC4 can be found in the user guide. Sequence Information:

      1. SigmaMAb Heavy Chain:
      EVQLVESGGGLVQPGGSLRLSCVASGFTLNNYD MHWVRQGIGKGLEWVSKIGTAGDRYYAGSVKGR FTISRENAKDSLYLQMNSLRVGDAAVYYCARGAG RWAPLGAFDIWGQGTMVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGA LTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ TYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCP APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVD VSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNS TYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPI EKTISKAKGQPREPQVYTLPPSRDELTKNQVSLT CLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDS DGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NHYTQKSLSLSPG

      2. SigmaMAb Light Chain:
      QSALTQPRSVSGSPGQSVTISCTGTSSDIGGYNF VSWYQQHPGKAPKLMIYDATKRPSGVPDRFSGS KSGNTASLTISGLQAEDEADYYCCSYAGDYTPGV VFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANK ATLVCLISDFYPGAVTVAWKADSSPVKAGVETTT PSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVT HEGSTVEKTVAPTECS

      Helpful?

  2. Does MSQC8 (SigmaMAb Antibody Drug Conjugate (ADC) Mimic) has light chain lambda or gamma?

    1 answer

    1. This antibody has both lambda light chains and gamma heavy chains.

      Helpful?

  3. What is the exact buffer composition of the reconstituted product?

    0 answers

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