234610

Congo Red, High Purity

An amyloidophylic dye that specifically stains stacked β sheet aggregates.

• Synonyma: Congo Red, High Purity, 3,3ʹ-[(1,1ʹ-Biphenyl)-4,4ʹ-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na
• Empirický vzorec (Hillův zápis): C₃₂H₂₂N₆O₆S₂ · 2Na
• Číslo CAS: 573-58-0
• Molekulová hmotnost: 696.66
• UNSPSC Code: 12171500
• NACRES: NA.25
• MDL number: MFCD00004028

Vlastnosti

• Quality Segment: 100
• description: Merck USA index - 14, 2498
• assay: ≥75% dye basis
• form: crystalline solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: rust
• solubility: water: 10 mg/mL, ethanol: soluble
• shipped in: ambient
• storage temp.: 15-25°C
• SMILES string: [Na+].[Na+].[S](=O)(=O)([O-])c1c2c(c(c(c1)N=Nc3ccc(cc3)c4ccc(cc4)N=Nc5c(c6c(c(c5)[S](=O)(=O)[O-])cccc6)N)N)cccc2
• InChI: 1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2
• InChI key: IQFVPQOLBLOTPF-UHFFFAOYSA-L

Popis

General description

An amyloidophylic dye that specifically stains stacked β sheet aggre-gates. Useful for staining and visual detection of amyloid deposits in nerve tissue. Binds to amyloid fibrils but not to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the normal isoform possibly through overstabilization of the conformation. It is also shown to inhibit Pot1 Binding to Telomeric DNA.

Biochem/physiol Actions

Cell permeable: no

Primary Target
An amyloidophylic dye that specifically stains stacked β sheet aggregates

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).

Other Notes

Altschuler, S.E., et al. 2012. Biochemistrin press.
Khurana, R., et al. 2001. J. Biol. Chem.276, 22715.
Fezoui, Y., et al. 2000. Amyloid7, 166.
Fezoui, Y., et al. 2000. Nat. Struct. Biol.7, 1095.
Kramport, M., et al. 2000. Chem. Biol.7, 855.
Kuner, P., et al. 2000. J. Biol. Chem.275, 1673.
Caspi, S., et al. 1998. J. Biol. Chem.273, 3484.
Caughey, B., and Race, A.E. 1992. J. Neurochem.59, 768.
Taylor, D.L., et al. 1974. J. Histochem. Cytochem.22, 1105.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Bezpečnostní informace

• Piktogramy: GHS08
• Výstražné slovo: Danger
• Kódy nebezpečí: H350,H361d
• Bezpečnostní pokyny: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 1B - Repr. 2
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co se děje?: WGK 3