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52332

Phenylmethylsulfonyl Fluoride

Name: Phenylmethylsulfonyl Fluoride
Brand: MM
Price: 1450 CZK

Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.

Synonyma:

Phenylmethylsulfonyl Fluoride, Benzylsulfonyl Fluoride, PMSF

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Vám/Skladová položka	Dostupnost	Cena
1 g	Zkontrolujte dostupnost v košíku	1 450,00 Kč
5 g	Zkontrolujte dostupnost v košíku	4 080,00 Kč
25 g	Zkontrolujte dostupnost v košíku	6 960,00 Kč

O této položce

Lineární vzorec:

C₆H₅CH₂SO₂F

Číslo CAS:

329-98-6

Molekulová hmotnost:

174.19

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00007424

Assay:

≥99% (GC)

Form:

crystalline solid

Storage condition:

OK to freeze, desiccated

1 450,00 Kč

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Vlastnosti

Quality Segment

200

description

RTECS - XT8040000

assay

≥99% (GC)

form

crystalline solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated

color

white to off-white

solubility

ethanol: soluble, isopropanol: soluble, methanol: soluble

shipped in

ambient

storage temp.

10-30°C

SMILES string

F[S](=O)(=O)Cc1ccccc1

InChI

1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2

InChI key

YBYRMVIVWMBXKQ-UHFFFAOYSA-N

Popis

General description

Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).

Biochem/physiol Actions

Cell permeable: no

Primary Target
serine proteases

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.

t_½ = 1 hour at pH 7.5. Effective concentration: 50 μM.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Seitz, R., et al. 1993. Int. J. Cancer53, 514.
Weaver, V.M., et al. 1993. Biochem. Cell. Biol.71, 488.
Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol.316, 427.
Chang, C.T., et al. 1992. Biochem. Int.28, 707.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Corrosive (L)

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Tato položka	178281	P7626	78830
Sigma-Aldrich 52332 Phenylmethylsulfonyl Fluoride	Sigma-Aldrich 178281 p-APMSF, Hydrochloride	Sigma-Aldrich P7626 Phenylmethanesulfonyl fluoride	Sigma-Aldrich 78830 Phenylmethanesulfonyl fluoride
description Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.	description Alternative to DFP and PMSF.	description ≥98.5% (GC)	description ≥99.0% (T)
assay ≥99% (GC)	assay ≥97% (HPLC)	assay ≥98.5% (GC)	assay ≥99.0% (T)
form crystalline solid	form solid	form powder	form powder or crystals
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename -
Quality Level 200	Quality Level 100	Quality Level 300	Quality Level 200
storage temp. 10-30°C	storage temp. 2-8°C	storage temp. -	storage temp. room temp
solubility ethanol: soluble, methanol: soluble, isopropanol: soluble	solubility water: 25 mg/mL	solubility H₂O: unstable, dry solvents (ethanol, methanol, and 2-propanol): 200 mM (Stock solution are stable for months at 4°C.)	solubility anhydrous isopropanol: soluble 35 mg/mL, clear to faintly hazy, colorless to faintly yellow (Heating required)

pictograms

GHS06,GHS05

signalword

Danger

hcodes

H301,H314

pcodes

P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363

Hazard Classifications

Acute Tox. 3 Oral - Skin Corr. 1B

Skladovací třída

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c