932191

SPhos ChemBeads

solid

• Synonyma: 2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl, S Phos, SPhos
• Empirický vzorec (Hillův zápis): C₂₆H₃₅O₂P
• Číslo CAS: 657408-07-6
• Molekulová hmotnost: 410.53
• MDL number: MFCD05861611
• UNSPSC Code: 12352128
• NACRES: NA.22

Vlastnosti

• Název produktu: SPhos ChemBeads,
• Quality Segment: 100
• product line: ChemBeads
• form: solid
• reaction suitability: reagent type: catalyst; reaction type: Cross Couplings
• sustainability: Sustainability features
• SMILES string: P(C4CCCCC4)(C3CCCCC3)c1c(cccc1)c2c(cccc2OC)OC
• InChI: 1S/C26H35O2P/c1-27-23-17-11-18-24(28-2)26(23)22-16-9-10-19-25(22)29(20-12-5-3-6-13-20)21-14-7-4-8-15-21/h9-11,16-21H,3-8,12-15H2,1-2H3
• InChI key: VNFWTIYUKDMAOP-UHFFFAOYSA-N

Popis

General description

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SPhos [2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

Application

SPhos may be used as a ligand in the following processes:

• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.
• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.
• Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.

Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation.
Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls.

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

Learn more about ChemBeads products

Product is also available as neat ligand (638072)

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• Co se děje?: WGK 3
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable