A3537

5-Aminosalicylic acid

powder, ≥99%

• Synonyma: 5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine
• Lineární vzorec: H₂NC₆H₃-2-(OH)CO₂H
• Číslo CAS: 89-57-6
• Molekulová hmotnost: 153.14
• NACRES: NA.83
• PubChem Substance ID: 24890780
• UNSPSC Code: 12352204
• EC Number: 201-919-1
• MDL number: MFCD00007877
• Beilstein/REAXYS Number: 2090421

Vlastnosti

• Název produktu: 5-Aminosalicylic acid, ≥99%
• Quality Segment: 200
• assay: ≥99%
• form: powder
• technique(s): protein detection: suitable
• color: off-white to gray
• mp: 275-280 °C (dec.) (lit.)
• solubility: 1 M HCl: 50 mg/mL, clear, yellow to brown
• storage temp.: 2-8°C
• SMILES string: Nc1ccc(O)c(c1)C(O)=O
• InChI: 1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
• InChI key: KBOPZPXVLCULAV-UHFFFAOYSA-N
• Gene Information: human ... ALOX5(240), PPARG(5468), PTGS1(5742), PTGS2(5743)

Popis

Application

5-Aminosalicylic acid (5-ASA) has been used:

• to synthesize 5-formyl-aminosalicylate-inulin to quantify its release during in vitro digestion and fermentation and compare the in vitro fermentation properties of the conjugated inulin to native inulin
• in cell adhesion assay to study its effects on E-cadherin glycosylation and membranous turnover
• to evaluate its effects on the neutrophilic inflammation index (NII) phenotype to study the effectiveness of the high cholesterol diet-gut inflammation (HCD-GI) platform

5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.

Biochem/physiol Actions

5-Aminosalicylic acid (5-ASA) is a first-line medicine, used to treat inflammatory bowel diseases like ulcerative colitis (UC). It has a high-efficiency rate in maintenance and induction of remission. 5-ASA is an active component of sulfasalazine and also consists of the carbohydrate polymer, inulin. It might exhibit anti-oxidant activity to lessen tissue injury. 5-ASA is vital for the prevention of T cell activation and proliferation. It negatively regulates cyclooxygenase and lipoxygenase pathways and lowers the formation of prostaglandins and leukotrienes. 5-ASA stimulates the membranous expression of E-cadherin and boosts intercellular adhesion.

Bezpečnostní informace

• Piktogramy: GHS07
• Výstražné slovo: Warning
• Kódy nebezpečí: H315,H317,H319,H335
• Bezpečnostní pokyny: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Cílové orgány: Respiratory system
• Skladovací třída: 11 - Combustible Solids
• WGK: WGK 2
• Bod vzplanutí (°F): No data available
• Bod vzplanutí (°C): No data available
• PPE (osobní ochranné prostředky): dust mask type N95 (US), Eyeshields, Gloves