The solution stability of this product has not been determined. However, an identical product, 219557, notes that solutions prepared in organic solvents, such as acetone, may be stored protected from light at -20°C for up to 3 months. It is recommended that aqueous solutions not be stored for more than 1 day.
C2389
Cerulenin
from Cephalosporium caerulens, ≥98% (HPLC), powder, de novo phospholipid synthesis inhibitor
Synonyma:
Helicocerin, (2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide
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| Vám/Skladová položka | Dostupnost | Cena |
|---|---|---|
5 mg | Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti. | 4 050,00 Kč |
10 mg | Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti. | 8 650,00 Kč 7 352,50 Kč |
50 mg | Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti. | 30 000,00 Kč |
O této položce
Empirický vzorec (Hillův zápis):
C12H17NO3
Číslo CAS:
Molekulová hmotnost:
223.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
241-424-8
MDL number:
Beilstein/REAXYS Number:
4140423
Assay:
≥98% (HPLC)
Form:
powder
4 050,00 Kč
Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.
Technický servis
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Dovolte nám, abychom vám pomohliNázev produktu
Cerulenin, ≥98% (HPLC), from Cephalosporium caerulens
biological source
Cephalosporium caerulens
Quality Segment
assay
≥98% (HPLC)
form
powder
mp
93 °C
solubility
acetone: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to yellow
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
storage temp.
−20°C
SMILES string
C/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O
InChI
1S/C13H18O3/c1-3-4-5-6-7-8-9-11(15)13-12(16-13)10(2)14/h3-4,6-7,12-13H,5,8-9H2,1-2H3/b4-3+,7-6+/t12-,13+/m0/s1
InChI key
PTNNGEBMCNMENY-JIVMHGEESA-N
Gene Information
human ... FASN(2194)
General description
Cerulenin, an inhibitor of de novo phospholipid synthesis triggers apoptosis in various wild type p53 and mutant p53 tumor cell lines. This fungal antibiotic also blocks the condensing enzyme involved in fatty acid and polyketide biosynthesis.
Application
Cerulenin has been used:
- as a fatty acid synthase inhibitor to study its effects on aldosterone-induced trained immunity[1]
- as a blocker of fatty acid synthase to study its effects on the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)[2]
- as a supplement in yeast extract–peptone–dextrose/glycerol (YPD/G) agar plates for the isolation of cerulenin-resistant yeast strains[3]
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Tato položka | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay 95% (HPLC) | assay ≥99% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility acetone: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to yellow | solubility H2O: complete 20 mg/ml, clear, colorless to light yellow, H2O: soluble | solubility 0.1 M HCl: 10 mg/mL | solubility DMSO: 50 mg/mL (can be stored frozen for several months), methanol: soluble 50 mg/mL, clear, colorless (undergoes transesterification) |
| Gene Information human ... FASN(2194) | Gene Information - | Gene Information - | Gene Information human ... BCL2(596), TUBA1A(7846), TUBA1B(10376), TUBA1C(84790), TUBA3C(7278), TUBA3E(112714), TUBA4A(7277), TUBB(203068), TUBB1(81027), TUBB2A(7280), TUBB2B(347733), TUBB3(10381), TUBB4A(10382), TUBB4B(10383), TUBB6(84617), TUBB8(347688) |
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