H3160

Hydrocortisone

meets USP testing specifications

• Synonyma: 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M
• Empirický vzorec (Hillův zápis): C₂₁H₃₀O₅
• Číslo CAS: 50-23-7
• Molekulová hmotnost: 362.46
• UNSPSC Code: 51111800
• NACRES: NA.21
• PubChem Substance ID: 24895560
• EC Number: 200-020-1
• Beilstein/REAXYS Number: 1354819
• MDL number: MFCD00011654

Vlastnosti

• biological source: plant (wild yam)
• Quality Segment: 300
• agency: USP/NF, meets USP testing specifications
• assay: 97.0-102.0% dry basis
• form: powder
• potency: 0.004-0.005 μg/mL
• mp: 211-214 °C (lit.)
• solubility: water: soluble 0.28 g/L at 25 °C
• application(s): pharmaceutical (small molecule)
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: JYGXADMDTFJGBT-VWUMJDOOSA-N
• Gene Information: human ... ABCB1(5243), CYP3A4(1576), NR3C1(2908), SERPINA6(866) ; mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126) ; rat ... Ar(24208), Nr3c1(24413)

Popis

Application

• Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: This research presents a novel method for embedding hydrocortisone into bacterial cellulose using microemulsion systems, highlighting its potential for creating anti-inflammatory wound dressings, a significant advancement in pharmaceutical design and material science (Zahel et al., 2024).


• Research progress in the treatment of chronic fatigue syndrome through interventions targeting the hypothalamus-pituitary-adrenal axis: This review discusses the role of hydrocortisone in treating chronic fatigue syndrome by modulating the hypothalamus-pituitary-adrenal axis, providing a comprehensive overview of its therapeutic applications in endocrinology (Zhang and Wang, 2024).

Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex.

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Bezpečnostní informace

• Piktogramy: GHS08
• Výstražné slovo: Danger
• Kódy nebezpečí: H360Df,H373
• Bezpečnostní pokyny: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1A - STOT RE 2
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable
• PPE (osobní ochranné prostředky): dust mask type N95 (US), Eyeshields, Gloves
• Cílové orgány: Adrenal gland,Bone marrow