If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
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For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
M0503
Mitomycin C from Streptomyces caespitosus
powder, contains NaCl as solubilizer
Vybrat velikost
| Vám/SKU | Dostupnost | Cena |
|---|---|---|
2 mg | Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti. | 4 910,00 Kč |
5 x 2 mg | Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti. | 17 500,00 Kč |
10 x 2 mg | Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti. | 32 200,00 Kč |
50 x 2 mg | Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti. | 123 000,00 Kč 92 250,00 Kč |
O této položce
4 910,00 Kč
biological source
Streptomyces caespitosus
Quality Segment
form
powder
contains
NaCl as solubilizer
color
gray, purple/blue
(1) 3.2, (2) 6.5
solubility
H2O: 1 vial + 4 mL, clear to slightly hazy, blue to purple
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
[H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(N)=C(C)C4=O
InChI
1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChI key
NWIBSHFKIJFRCO-WUDYKRTCSA-N
General description
Application
Biochem/physiol Actions
Antimicrobial Spectrum: Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria.
Preparation Note
Disclaimer
1 of 1
Tato položka | |||
|---|---|---|---|
| description powder, contains NaCl as solubilizer | description meets USP testing specifications | description powder, BioReagent, suitable for cell culture | description ≥98% (HPLC), γ-irradiated, suitable for cell culture |
| mode of action DNA synthesis | interferes | mode of action DNA synthesis | interferes | mode of action DNA synthesis | interferes | mode of action DNA synthesis | interferes |
| antibiotic activity spectrum Gram-positive bacteria, Gram-negative bacteria | antibiotic activity spectrum Gram-positive bacteria, Gram-negative bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-positive bacteria, Gram-negative bacteria, neoplastics |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form - | form powder | form powder or crystals |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility H2O: 1 vial + 4 mL, clear to slightly hazy, blue to purple | solubility H2O: soluble, H2O: 40 mg/mL, clear to very slightly hazy, colorless | solubility H2O: 4 mL/vial, clear to slightly hazy, blue to purple (Stock solutions should be filter sterilized and stored at 2-8 °C in the dark.) | solubility DMSO: 1.0 mg/mL |
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Výstražné slovo
Warning
Kódy nebezpečí
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2
Skladovací třída
11 - Combustible Solids
Bod vzplanutí (°F)
Not applicable
Bod vzplanutí (°C)
Not applicable
Bezpečnostní pokyny
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
Helpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Is Mitomycin C, Product M0503, soluble in PBS?
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According to literature resources, the solubility of Mitomycin C in phosphate-buffered saline (PBS) is between 0.5 to 1.0 mg/mL depending on the exact ambient temperature.
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Is Mitomycin C, Product M0503, light sensitive?
1 answer-
Mitomycin C is light sensitive only when in solution and not as a powder.
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Why does Mitomycin C, Product M0503, contain NaCl?
1 answer-
Sodium chloride is added to mitomycin C to increase solubility and solution stability.
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How do I store a stock solution of Mitomycin C, Product M0503?
1 answer-
Generally, solutions at pH 6-9 can be stored at 0-5 °C for up to a week, and possibly much longer. If a precipitate forms, a fresh solution should be prepared. The precipitated solution has proven to be toxic to cells. A stock solution should also be stored in the dark since mitomycin C is readily decomposed by light. Solutions should not be frozen, since a precipitate is likely to form.
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How do I use Mitomycin C, Product M0503, to block replication?
1 answer-
Cell functions that require cellular division are abolished by treatment with mitomycin C (causes DNA crosslinking). This can be used to treat cells for feeder layers, for mixed lymphocyte reactions and for removal of fibroblasts from mixed cell cultures. Mitomycin is used at 25 μg/mL to treat cells at 1 - 6 × 107 cells/mL. Cells are treated for 25 minutes at 37 °C. Selected Methods in Cellular Immunology, Michell, BB, and Shiigi, SM, Eds., WH Freeman and Co., New York, 1980, p. 240.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the difference between Mitomycin C Product No. M0503 and M4287?
1 answer-
The difference between Product Nos. M0503 and M4287 is that Product No. M4287 has been tested on cells. A feeder layer is treated with media containing 10 μg/mL mitomycin C for 3 hours at 37°C to block replication.
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