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Merck

BP466

Cyanocobalamin

British Pharmacopoeia (BP) Assay Standard

Synonym(s):

Vitamin B12, α-(5,6-Dimethylbenzimidazolyl)cyanocobamide, CN-Cbl, Cyanocob(III)alamin, Cyanocobalamin

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150 MG

CZK 5,440.00

CZK 5,440.00


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About This Item

Empirical Formula (Hill Notation):
C63H88CoN14O14P
CAS Number:
Molecular Weight:
1355.37
NACRES:
NA.24
UNSPSC Code:
41116107
MDL number:
EC Number:
200-680-0
Beilstein/REAXYS Number:
4122889

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Product Name

Cyanocobalamin, British Pharmacopoeia (BP) Assay Standard

InChI key

RMRCNWBMXRMIRW-QJRSUKKJSA-L

InChI

1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1

SMILES string

C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@

grade

pharmaceutical primary standard

API family

cyanocobalamin

form

solid

manufacturer/tradename

BP

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

color

light red

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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1 of 4

This Item
C3000000431071152011
grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

-

grade

pharmaceutical primary standard

format

neat

format

neat

format

-

format

neat

API family

cyanocobalamin

API family

cyanocobalamin

API family

-

API family

cyanocobalamin

form

solid

form

solid

form

powder

form

-

manufacturer/tradename

BP

manufacturer/tradename

EDQM

manufacturer/tradename

-

manufacturer/tradename

USP

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

-

technique(s)

-

Application

Cyanocobalamin BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Cyanocobalamin Tablets
  • Cyanocobalamin Oral Solution
  • General description

    This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. Cyanocobalamin is a water soluble vitamin,[1] which plays an important role in animal and plant metabolism.[2]

    Other Notes

    Sales restrictions may apply.
    Learn how British Pharmacopoeia (BP) sets the standard by offering quality British Pharmacopoeia Chemical Reference Substances (BPCRS).

    Packaging

    Unit quantity: 150 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Storage Class

    11 - Combustible Solids

    wgk

    WGK 1


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    Ultramicrodetermination of cyanocobalamin in elemental diet by solid-phase extraction and high-performance liquid chromatography with visible detection
    Iwase H
    Journal of Chromatography A, 590(2), 359-363 (1992)
    Quantitative simultaneous estimation of water-soluble vitamins, Riboflavin, Pyridoxine, Cyanocobalamin and Folic Acid in neutraceutical products by HPLC
    Perveen S, et al.
    The Open Analytical Chemistry Journal, 3, 1-5 (2009)
    Marzia Dolcino et al.
    PloS one, 9(5), e97571-e97571 (2014-05-17)
    Regular intravenous immunoglobulin treatment is used to replace antibody deficiency in primary immunodeficiency diseases; however the therapeutic effect seems to be related not only to antibody replacement but also to an active role in the modulation of the immune response.
    David Preiss et al.
    The lancet. Diabetes & endocrinology, 2(2), 116-124 (2014-03-14)
    Metformin reduces cardiovascular risk in patients with type 2 diabetes seemingly independent of lowering blood glucose concentration. We assessed the cardiovascular effects of metformin in individuals without type 2 diabetes. We did a single-centre, double-blind, placebo-controlled trial at the Glasgow
    Esko J Wiltshire et al.
    The Journal of pediatrics, 166(2), 319-325 (2014-12-06)
    To determine the effect of polymorphisms in NOS3 and folate pathway enzymes on vascular function and folate status and endothelial response to folate in children with diabetes or obesity. A total of 244 subjects (age 13.8 ± 2.8 years, 125

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