C1290

Chlorpropamide

Name: Chlorpropamide
Brand: SIAL
Price: 2193 CZK

analytical standard, ≥97%

Synonym(s):

1-(p-Chlorobenzenesulfonyl)-3-propylurea

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25 G

CZK 2,193.00

List PriceCZK 2,580.00Save 15%

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₃ClN₂O₃S

CAS Number:

94-20-2

Molecular Weight:

276.74

NACRES:

NA.24

PubChem Substance ID:

329774748

UNSPSC Code:

41116107

EC Number:

202-314-5

MDL number:

MFCD00079004

Key Documents

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Product Name

Chlorpropamide, analytical standard, ≥97%

InChI key

RKWGIWYCVPQPMF-UHFFFAOYSA-N

InChI

1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14)

SMILES string

CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1

grade

analytical standard

assay

≥97%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

100

Gene Information

human ... ABCC8(6833), ALB(213), EPHX2(2053), KCNJ1(3758), KCNJ11(3767)
mouse ... Ephx2(13850)

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Controlled Substances & Illicit Drug Standards

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Show Differences

1 of 4

This Item	1126009	C1905000	31679
Supelco C1290 Chlorpropamide	USP 1126009 Chlorpropamide	C1905000 Chlorpropamide	Supelco 31679 Chlorpromazine hydrochloride
grade analytical standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade analytical standard
format neat	format neat	format neat	format neat
assay ≥97%	assay -	assay -	assay -
technique(s) HPLC: suitable	technique(s) -	technique(s) -	technique(s) HPLC: suitable, gas chromatography (GC): suitable
application(s) forensics and toxicology pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) forensics and toxicology pharmaceutical (small molecule)
Quality Level 100	Quality Level -	Quality Level -	Quality Level 100

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Chlorpropamide is a drug that belongs to the sulfonylurea family.[1] It is an effective candidate in the treatment of diabetes insipidus.[2]

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H361f

pcodes

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Investigation of the Factors Responsible for the Poor Oral Bioavailability of Acacetin in Rats: Physicochemical and Biopharmaceutical Aspects.

Dong-Gyun Han et al.

Pharmaceutics, 13(2) (2021-02-03)

Acacetin, an important ingredient of acacia honey and a component of several medicinal plants, exhibits therapeutic effects such as antioxidative, anticancer, anti-inflammatory, and anti-plasmodial activities. However, to date, studies reporting a systematic investigation of the in vivo fate of orally

Worst Pills, Best Pills: A Consumer's Guide to Preventing Drug-Induced Deat (2009)

Evaluation of the microstructure of semicrystalline solid dispersions.

Qing Zhu et al.

Molecular pharmaceutics, 7(4), 1291-1300 (2010-06-17)

As a result of an increase in the number of emerging therapies with dissolution limited bioavailability, formulation strategies such as solid dispersions that enhance the rate of solubilization are of interest. In this study, the microstructure of solid dispersions prepared

A high-pressure polymorph of chlorpropamide formed on hydrostatic compression of the α-form in saturated ethanol solution.

Yury V Seryotkin et al.

Acta crystallographica. Section B, Structural science, 69(Pt 1), 77-85 (2013-02-01)

The crystal structure of the high-pressure polymorph (α') of an antidiabetic drug, chlorpropamide [4-chloro-N-(propylaminocarbonyl)benzenesulfonamide, C(10)H(13)ClN(2)O(3)S], which is formed at ~2.8 GPa from the α-polymorph (P2(1)2(1)2(1)) on hydrostatic compression in saturated ethanol solution, has been determined. As a result of the

Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer.

Jer-Yen Yang et al.

Cancer research, 70(11), 4709-4718 (2010-05-21)

Drug resistance is a central challenge of cancer therapy that ultimately leads to treatment failure. In this study, we characterized a mechanism of drug resistance that arises to AZD6244, an established mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) 1/2 inhibitor currently

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